Devogelaer J P, Nagant de Deuxchaisnes C, Stein F
Department of Rheumatology, Louvain University, Brussels, Belgium.
J Bone Miner Res. 1990 Mar;5 Suppl 1:S75-9. doi: 10.1002/jbmr.5650051311.
The gastrointestinal absorption of enteric-coated (EC) tablets of sodium fluoride (NaF) with respect to different time schedules of administration of calcium supplements in solution was tested. It was found that the simultaneous administration of these two medications under these formulations did not interfere with fluoride absorption. The calcium was also well absorbed as shown by the rise in serum ionized calcium concentration. Other schedules were studied as well, such as EC NaF tablets taken 1 hour after or 3 hours before the administration of calcium supplements. No superiority was shown, on the contrary, compared with the simultaneous administration of both medications. It was concluded that EC tablets of NaF and calcium supplements in solution can be provided simultaneously to enhance compliance.
测试了在不同时间安排服用溶液中钙补充剂的情况下，氟化钠（NaF）肠溶（EC）片的胃肠道吸收情况。结果发现，在这些制剂下同时服用这两种药物不会干扰氟的吸收。血清离子钙浓度升高表明钙也吸收良好。还研究了其他给药方案，如在服用钙补充剂1小时后或3小时前服用EC NaF片。相反，与同时服用两种药物相比，未显示出优势。得出的结论是，可以同时提供NaF的EC片和溶液中的钙补充剂，以提高依从性。
