Department of Neurology, Miller School of Medicine, University of Miami, Clinical Research Building, Miami, FL 33136, USA.
Metab Brain Dis. 2013 Sep;28(3):337-9. doi: 10.1007/s11011-013-9385-3. Epub 2013 Feb 10.
Diabetes is one of the most important risk factor for stroke and cardiovascular disease (CVD), especially in young patients. The control of classical vascular risk factors failed in terms of prevention of stroke in patients with diabetes. In addiction, in these patients the glycemic control showed a benefit on microvascular disease but lacked an established benefit in macrovascular disease. Therefore, implementations of effective stroke prevention strategies appear necessary in patients with diabetes. Ultrasound surrogate or intermediate markers of carotid atherosclerosis include carotid intima-media thickness (cIMT), carotid plaque (CP), and carotid stiffness (STIFF) have been demonstrated to increase in patients with diabetes and to be able to predict risk for stroke. In this editorial we discuss the opportunity to prevent the onset of vascular disease in their "preclinical or subclinical" stage in patients with higher risk for stroke such as diabetic patients.
糖尿病是中风和心血管疾病（CVD）的最重要危险因素之一，尤其是在年轻患者中。控制经典的血管危险因素并不能预防糖尿病患者的中风。此外，在这些患者中，血糖控制对微血管疾病有益，但对大血管疾病没有明确的益处。因此，对于糖尿病患者来说，实施有效的中风预防策略是必要的。已经证明，颈动脉粥样硬化的超声替代或中间标志物，包括颈动脉内膜中层厚度（cIMT）、颈动脉斑块（CP）和颈动脉僵硬度（STIFF）在糖尿病患者中增加，并能够预测中风风险。在这篇社论中，我们讨论了在具有更高中风风险（如糖尿病患者）的患者的“临床前或亚临床”阶段预防血管疾病发生的机会。
