脂肪组织巨噬细胞在肥胖诱导的炎症、胰岛素抵抗和 2 型糖尿病的发生发展中的作用。
Adipose tissue macrophages in the development of obesity-induced inflammation, insulin resistance and type 2 diabetes.
机构信息
Joslin Diabetes Center, Harvard Medical School, One Joslin Place, Boston, MA 02115, USA.
出版信息
Arch Pharm Res. 2013 Feb;36(2):208-22. doi: 10.1007/s12272-013-0023-8. Epub 2013 Feb 10.
Abstract
It has been increasingly accepted that chronic subacute inflammation plays an important role in the development of insulin resistance and type 2 diabetes in animals and humans. Particularly supporting this is that suppression of systemic inflammation in type 2 diabetes improves glycemic control; this also points to a new potential therapeutic target for the treatment of type 2 diabetes. Recent studies strongly suggest that obesity-induced inflammation is mainly mediated by tissue resident immune cells, with particular attention being focused on adipose tissue macrophages (ATMs). This review delineates the current progress made in understanding obesity-induced inflammation and the roles ATMs play in this process.
摘要
越来越多的人认为，慢性亚急性炎症在动物和人类胰岛素抵抗和 2 型糖尿病的发展中起着重要作用。特别支持这一观点的是，在 2 型糖尿病中抑制全身炎症可改善血糖控制；这也为 2 型糖尿病的治疗指出了一个新的潜在治疗靶点。最近的研究强烈表明，肥胖引起的炎症主要是由组织驻留免疫细胞介导的，特别关注脂肪组织巨噬细胞 (ATMs)。这篇综述阐述了目前在理解肥胖引起的炎症以及 ATMs 在这一过程中所起的作用方面所取得的进展。
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