Selcuklu Tip Fakultesi, Kardiyoloji AD, Selcuk Universitesi, 42075, Kampus, Konya, Turkey.
Cardiovasc Toxicol. 2013 Sep;13(3):230-3. doi: 10.1007/s12012-013-9201-7.
Intoxication caused by propafenone is very rare, and there is no case reported before propafenone and captopril intoxication together. There are few case reports in the literature about intoxication with more than 6 g of propafenone. We present the clinical manifestation and successfully treatment of 9 g of propafenone and 1 g captopril intoxication in an 18-year-old female. An 18-year-old female was brought to the emergency department approximately half an hour after she committed suicide with 30 propafenone tablets, 300 mg each, and 20 captopril tablets, 50 mg each. Her fist electrocardiography (ECG) shows a chaotic ventricular rhythm with a prolonged QRS complex. After fluid and sodium bicarbonate infusion and permanent pacemaker implantation, sinus rhythm was achieved. This case, to our knowledge, is the first in that it describes the successful recovery of a patient who ingested extensively large doses of propafenone (9 g) and captopril (1 g), both of which are known to have severe cardiac side effects.
普罗帕酮中毒非常罕见，且此前尚无同时合并普罗帕酮和卡托普利中毒的病例报告。文献中关于摄入超过 6 g 普罗帕酮中毒的病例报告也很少。我们报道了一例 18 岁女性同时摄入 9 g 普罗帕酮和 1 g 卡托普利中毒的临床表现和成功救治。一位 18 岁女性因自杀吞服 30 片普罗帕酮（每片 300 mg）和 20 片卡托普利（每片 50 mg）后约半小时被送至急诊室。她当时的首次心电图（ECG）显示出一种混乱的室性节律，伴有 QRS 波群延长。经过液体和碳酸氢钠输注以及永久性起搏器植入后，恢复了窦性节律。据我们所知，这是首例成功救治摄入大量普罗帕酮（9 g）和卡托普利（1 g）的患者的病例，这两种药物都已知具有严重的心脏副作用。
