内血视网膜屏障：分子结构和转运生物学。

The inner blood-retinal barrier: molecular structure and transport biology.

机构信息

Department of Pharmaceutics, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Sugitani, Toyama, Japan.

出版信息

Adv Exp Med Biol. 2012;763:85-104.

PMID:23397620

Abstract

The inner blood-retinal barrier (inner BRB) is created by complex tight junctions of retinal capillary endothelial cells. Although this barrier prevents the free diffusion of substances between the circulating blood and the neural retina, the inner BRB efficiently supplies nutrients to the retina and removes endobiotics and xenobiotics from the retina to maintain a constant milieu in the neural retina. We review herein the molecular structure and transport mechanism at the inner BRB.

摘要

血-视网膜内屏障（inner BRB）由视网膜毛细血管内皮细胞的复杂紧密连接形成。尽管该屏障可防止循环血液和神经视网膜之间的物质自由扩散，但 inner BRB 可有效地向视网膜供应营养物质，并从视网膜中清除内源性和外源性物质，以维持神经视网膜内的恒定环境。本文综述了 inner BRB 的分子结构和转运机制。