两例因摄入γ-丁内酯（GBL）导致严重中毒，险些致命的病例。

Two cases of near-fatal gamma-butyrolactone (GBL) ingestion and intoxication.

作者信息

van Vugt R, Hofhuizen C M

机构信息

Radboud University Nijmegen Medical Centre, Department of Anaesthesiology, Pain Treatment and Palliative Care, PO Box 9101, 6500 HB Nijmegen, The Netherlands.

出版信息

Acta Anaesthesiol Belg. 2012;63(3):139-41.

PMID:23397667

Abstract

We present two cases of GBL intoxication. Patient A is a 45-year old man who lost consciousness after drinking a clear unknown liquid. He was brought to the Emergency Departement (ED) after he was intubated. His partner notified the liquid could be GBL, a prodrug for GHB. He regained consciousness 16 hours later in the intensive care unit (ICU) where he could be successfully extubated. Patient B is a 25-year old man who was found unconscious at home with next to him an empty bottle of GBL. He was intubated in the intensive care unit. He could be extubated after 12 hours. GBL intoxication is becoming a more frequent problem and overdosage of GBL can rapidly occur because of its rapid onset and high potency when compared to GHB. We discuss the clinical course and complications after GBL ingestion and intoxication.

摘要

我们报告两例γ-丁内酯（GBL）中毒病例。患者A是一名45岁男性，饮用一种不明澄清液体后失去意识。插管后他被送往急诊科（ED）。其伴侣告知该液体可能是GBL，一种γ-羟基丁酸（GHB）的前体药物。16小时后他在重症监护病房（ICU）恢复意识，并成功拔管。患者B是一名25岁男性，在家中被发现昏迷，旁边有一个空的GBL瓶子。他在重症监护病房接受了插管。12小时后他得以拔管。GBL中毒正成为一个日益常见的问题，与GHB相比，由于GBL起效迅速且效力高，GBL过量服用可能迅速发生。我们讨论了GBL摄入和中毒后的临床过程及并发症。