Department of Allergy, Hospital La Paz Institute for Health Research (IdiPAZ), Madrid, Spain.
J Investig Allergol Clin Immunol. 2012;22(7):460-75; quiz 2 p following 475.
The concepts of asthma severity, control, and exacerbation are important in the evaluation of patients and their response to treatment. However, terminology is not standardized, and terms are often used interchangeably. Patients with uncontrolled severe asthma pose a major health care problem. Over the last decade, it has become increasingly clear that, in order to facilitate the development of novel targeted therapies, patients must be further characterized and classified.
To draft a consensus statement on the diagnosis, management, and treatment of severe uncontrolled asthma. The statement is meant to serve as a guideline for health professionals and clinical researchers.
The consensus was led by the Severe Asthma Working Group of the Spanish Society of Allergology and Clinical ImmunologyAsthma Committee. A review was conducted of the best available scientific evidence (until December 2011) on severe asthma in adults and children.
Definitions for severe asthma, level of control, and exacerbation are developed. Different phenotypes and endophenotypes of severe uncontrolled asthma and new specific therapeutic interventions are presented. A systematic algorithm for the evaluation of patients presenting with severe persistent asthma symptoms is proposed.
A consensus statement on the diagnosis, management, and treatment of severe uncontrolled asthma is presented.
哮喘严重程度、控制和恶化的概念在评估患者及其对治疗的反应中非常重要。然而，术语并未标准化，并且经常互换使用。未得到控制的严重哮喘患者构成了重大的医疗保健问题。在过去十年中，越来越明显的是，为了促进新型靶向治疗的发展，必须进一步对患者进行特征描述和分类。
起草一份关于严重未控制哮喘的诊断、管理和治疗的共识声明。该声明旨在为卫生专业人员和临床研究人员提供指南。
共识由西班牙过敏与临床免疫学学会哮喘委员会的严重哮喘工作组牵头。对成人和儿童严重哮喘的最佳现有科学证据（截至 2011 年 12 月）进行了审查。
制定了严重哮喘、控制水平和恶化的定义。提出了严重未控制哮喘的不同表型和内表型以及新的特定治疗干预措施。提出了一种用于评估出现严重持续性哮喘症状患者的系统算法。
提出了一份关于严重未控制哮喘的诊断、管理和治疗的共识声明。
