The Center for Insoluble Protein Structures, Department of Chemistry and the Interdisciplinary Nanoscience Center, Aarhus University, Gustavs Wieds Vej 14, 8000 Aarhus, Denmark.
J Am Chem Soc. 2013 Feb 27;135(8):2891-4. doi: 10.1021/ja3114032. Epub 2013 Feb 19.
A protocol for the Pd-catalyzed hydroxycarbonylation of aryl iodides, bromides, and chlorides has been developed using only 1-5 mol % of CO, corresponding to a p(CO) as low as 0.1 bar. Potassium formate is the only stoichiometric reagent, acting as a mildly basic nucleophile and a reservoir of CO. The substoichiometric CO could be delivered to the reaction from an acyl-Pd(II) precatalyst, which provides both the CO and an active catalyst, and thereby obviates the need for handling a toxic gas.
开发了一种使用仅 1-5 mol% CO（对应 p(CO) 低至 0.1 巴）的 Pd 催化芳基碘化物、溴化物和氯化物的羟羰基化反应的协议。甲酸钾是唯一的化学计量试剂，充当温和的亲核试剂和 CO 的储存库。亚化学计量的 CO 可以从酰基-Pd(II)前催化剂输送到反应中，该前催化剂提供 CO 和活性催化剂，从而避免了处理有毒气体的需要。
