炔基三唑通过炔烃-卡宾复分解步骤的分子内环化反应：得到稠合的吡咯。
Intramolecular transannulation of alkynyl triazoles via alkyne-carbene metathesis step: access to fused pyrroles.
机构信息
Department of Chemistry, University of Illinois at Chicago , 845 West Taylor Street, Chicago, Illinois 60607, United States.
出版信息
Org Lett. 2013 Oct 18;15(20):5394-6. doi: 10.1021/ol4027655. Epub 2013 Oct 4.
Abstract
An intramolecular Rh-catalyzed transannulation reaction of alkynyl triazoles has been developed. This method allows efficient construction of various 5,5-fused pyrroles, including tetrahydropyrrolo and spiro systems. The method demonstrates excellent functional group compatibility. A rhodium carbene-alkyne metathesis mechanism is proposed for this transformation.
摘要
发展了一种炔基三唑的分子内铑催化的 transannulation 反应。该方法可高效构建各种 5,5-稠合的吡咯，包括四氢吡咯和螺环系统。该方法表现出优异的官能团兼容性。提出了该转化的铑卡宾-炔烃交叉复分解反应机理。
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