Kilpatrick D, Webber S D, Colle J P
Department of Medicine, University of Tasmania, Hobart, Australia.
Angiology. 1990 Apr;41(4):278-85. doi: 10.1177/000331979004100404.
The vascular resistance of stenoses in series has been studied in vitro by use of fiber optic laser Doppler anemometry to measure the cross-sectional areas of the stenoses. Pressure gradients across each of the stenoses were measured while both the severity and the separation of the stenoses were altered. The individual resistances were compared with the combined resistance. Resistance at a stenosis is a nonlinear function of the severity of the stenosis. The resistance is a complex function of the perfusion pressure and the cross-sectional area of the stenosis and cannot be accurately predicted from a single plane angiographic image. With multiple stenoses an approximate assessment of the combined effect can be obtained by summing the value of the resistance for each stenosis but not the degree of the stenoses. The nonlinear relationship of resistance to stenosis severity means that if one stenosis is more severe than the other, the combined effect can be regarded as the same as the effect of the more severe stenosis acting by itself. The distance between the stenoses does not change their combined effect.
通过使用光纤激光多普勒血流仪测量狭窄的横截面积，在体外研究了串联狭窄的血管阻力。在改变狭窄的严重程度和间距的同时，测量了每个狭窄两端的压力梯度。将各个阻力与总阻力进行了比较。狭窄处的阻力是狭窄严重程度的非线性函数。阻力是灌注压力和狭窄横截面积的复杂函数，无法从单平面血管造影图像准确预测。对于多个狭窄，通过将每个狭窄的阻力值相加，可获得对总效应的近似评估，但不能将狭窄程度相加。阻力与狭窄严重程度的非线性关系意味着，如果一个狭窄比另一个更严重，则总效应可视为与单独作用的更严重狭窄的效应相同。狭窄之间的距离不会改变它们的总效应。
