Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Ling-Ling Road, Shanghai 200032, China.
J Am Chem Soc. 2013 Feb 27;135(8):2955-8. doi: 10.1021/ja312711c. Epub 2013 Feb 18.
An unprecedented silver-mediated vicinal trifluoromethylation-iodination of arynes that quickly introduces CF(3) and I groups onto aromatic rings in a single step to give o-trifluoromethyl iodoarenes has been developed. A new reactivity of AgCF(3) has been revealed, and 2,2,6,6-tetramethylpiperidine plays an important role in this difunctionalization reaction.
发展了一种前所未有的银介导的芳炔邻位三氟甲基化-碘化反应，该反应可在一步中快速将 CF(3)和 I 基团引入芳环，得到邻三氟甲基碘代芳烃。揭示了 AgCF(3) 的新反应性，2,2,6,6-四甲基哌啶在该双官能化反应中发挥了重要作用。
