Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China.
Departamento de Química Orgánica, Universidad de Valencia, 46100 Valencia, Spain.
Molecules. 2021 Nov 28;26(23):7221. doi: 10.3390/molecules26237221.
Incorporation of fluorine into organic molecules is a well-established strategy in the design of advanced materials, agrochemicals, and pharmaceuticals. Among numerous modern synthetic approaches, functionalization of unsaturated bonds with simultaneous addition of trifluoromethyl group along with other substituents is currently one of the most attractive methods undergoing wide-ranging development. In this review article, we discuss the most significant contributions made in this area during the last decade (2012-2021). The reactions reviewed in this work include chloro-, bromo-, iodo-, fluoro- and cyano-trifluoromethylation of alkenes and alkynes.
将氟原子引入有机分子中是设计先进材料、农用化学品和药物的一种成熟策略。在众多现代合成方法中，通过不饱和键的官能团化同时引入三氟甲基和其他取代基是目前正在广泛发展的最有吸引力的方法之一。在这篇综述文章中，我们讨论了过去十年（2012-2021 年）在该领域的最重要贡献。本文综述了烯烃和炔烃的氯代、溴代、碘代、氟代和氰基三氟甲基化反应。
