Department of Preventive Medicine, College of Basic Medical Sciences, Hubei University of Chinese Medicine, Wuhan, PR China.
Arch Med Res. 2013 Feb;44(2):127-35. doi: 10.1016/j.arcmed.2013.01.009. Epub 2013 Feb 8.
A large number of studies have investigated the correlation between the interleukin (IL)-4 C-589T and C+33T polymorphisms and asthma susceptibility. However, the results are inconsistent. The objective of this study is to explore the association between the IL-4 C-589T and C+33T polymorphisms and asthma risk using meta-analysis.
A total of 35 studies (31 concerning C-589T polymorphism and asthma risk with 4737 asthmatics and 6389 controls and 14 studies regarding C+33T polymorphism and asthma risk with 2544 asthmatics and 4049 controls) were included in this meta-analysis.
The IL-4 C-589T polymorphism was associated with increased asthma risk in a dominant genetic model (odds ratio [OR] [95% confidence interval (CI)] = 1.284 [1.131-1.459] for TT + TC vs. CC). In the subgroup analyses by ethnicity, age and atopic status of asthmatics, significantly increased risks of asthma were found both in Asians (OR [95% CI] = 1.301 [1.003-1.689]) and Caucasians (OR [95% CI] = 1.314 [1.061-1.628]) and in both adults (OR [95% CI] = 1.299 [1.098-1.537]) and children (OR [95% CI] = 1.464 [1.044-2.052]). As for the C+33T polymorphism, the results showed that it was correlated with elevated asthma risk in a recessive genetic model (OR [95% CI] = 1.744 [1.215-2.504] for TT vs. CT + CC). After stratifying analyses by ethnicity, age and atopic status of asthmatics, significantly increased asthma risks were observed in Asians (OR [95% CI] = 1.223 [1.037-1.442]), Caucasians (OR [95% CI] = 3.036 [1.224-7.529]), and children (OR [95% CI] = 1.300 [1.075-1.573]) in a recessive genetic model.
This meta-analysis suggests that the IL-4 C-589T and C+33T polymorphisms may be risk factors for asthma.
大量研究探讨了白细胞介素（IL）-4 C-589T 和 C+33T 多态性与哮喘易感性之间的相关性。然而，结果并不一致。本研究旨在通过荟萃分析探讨 IL-4 C-589T 和 C+33T 多态性与哮喘风险之间的关联。
本荟萃分析共纳入 35 项研究（31 项研究探讨 C-589T 多态性与哮喘风险的关系，涉及 4737 例哮喘患者和 6389 例对照，14 项研究探讨 C+33T 多态性与哮喘风险的关系，涉及 2544 例哮喘患者和 4049 例对照）。
IL-4 C-589T 多态性在显性遗传模型中与哮喘风险增加相关（TT+TC 与 CC 相比的比值比[OR] [95%置信区间（CI）] = 1.284 [1.131-1.459]）。在按种族、哮喘患者年龄和特应性状态进行的亚组分析中，亚洲人群（OR [95%CI] = 1.301 [1.003-1.689]）和白种人群（OR [95%CI] = 1.314 [1.061-1.628]）以及成年人（OR [95%CI] = 1.299 [1.098-1.537]）和儿童（OR [95%CI] = 1.464 [1.044-2.052]）中均发现哮喘风险显著增加。至于 C+33T 多态性，结果表明其在隐性遗传模型中与哮喘风险升高相关（TT 与 CT+CC 相比的 OR [95%CI] = 1.744 [1.215-2.504]）。在按种族、哮喘患者年龄和特应性状态进行的分层分析中，亚洲人群（OR [95%CI] = 1.223 [1.037-1.442]）、白种人群（OR [95%CI] = 3.036 [1.224-7.529]）和儿童（OR [95%CI] = 1.300 [1.075-1.573]）在隐性遗传模型中均观察到哮喘风险显著增加。
本荟萃分析表明，IL-4 C-589T 和 C+33T 多态性可能是哮喘的危险因素。
