Department of Infectious Diseases, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark.
Influenza Other Respir Viruses. 2013 Sep;7(5):776-82. doi: 10.1111/irv.12093. Epub 2013 Feb 9.
Denmark experienced three waves of the new pandemic influenza A (H1N1)pdm09 from July 2009 to February 2011. The aim of the study was to describe the epidemiology and clinical characteristics of hospitalized patients in a defined population of North Denmark Region with a mixed urban and rural community of 579,000 inhabitants.
Review of medical records of all hospitalized patients with confirmed influenza A from July 2009 to February 2011.
Two hundred and seventy-three patients were admitted to hospital. The age-related population incidences of hospitalization were as follows: 0-14 years: 111/100,000, 15-64 years: 39/100,000, and ≥ 65 years: 17/100,000. During the first wave (July 2009-August 2009), three patients were admitted - none received treatment in intensive care units (ICUs), during the second wave (October 2009-January 2010), 158 patients were admitted - nine received treatment in ICUs, and during the third wave (December 2010-February 2011), 112 patients were admitted - 25 received treatment in ICUs. Fourteen patients (5%) died within 30 days of diagnosis (median 55 years; range 14-76 years) and additional seven patients (2.6%) died within 365 days (median 25 years; range 1-86 years).
Patients hospitalized with pandemic influenza A (H1N1)pdm09 were predominantly children and younger adults, and only a few patients were >65 years. The third wave was the most severe taking the number and percentage of patients admitted to ICUs and 30-day mortality into consideration. We observed that the incidence of hospitalizations as well as clinical severity among younger adults did not decline from the second to the third wave.
丹麦经历了三波新型大流行性流感 A（H1N1）pdm09，从 2009 年 7 月到 2011 年 2 月。本研究的目的是描述丹麦北地区一个具有城市和农村混合社区的特定人群中，579000 居民中住院患者的流行病学和临床特征。
回顾分析 2009 年 7 月至 2011 年 2 月所有确诊甲型流感住院患者的病历。
273 名患者住院。按年龄计算的住院人口发病率如下：0-14 岁：111/100000，15-64 岁：39/100000，≥65 岁：17/100000。在第一波（2009 年 7 月至 8 月）期间，有 3 名患者住院-无一人在重症监护病房（ICU）接受治疗，在第二波（2009 年 10 月至 2010 年 1 月）期间，有 158 名患者住院-9 人在 ICU 接受治疗，在第三波（2010 年 12 月至 2011 年 2 月）期间，有 112 名患者住院-25 人在 ICU 接受治疗。诊断后 30 天内死亡的患者有 14 例（5%）（中位年龄 55 岁；范围 14-76 岁），另外 7 例（2.6%）在 365 天内死亡（中位年龄 25 岁；范围 1-86 岁）。
因大流行性流感 A（H1N1）pdm09 住院的患者主要为儿童和年轻成年人，只有少数患者年龄超过 65 岁。从 ICU 住院人数和 30 天死亡率来看，第三波疫情最为严重。我们观察到，年轻成年人的住院率和临床严重程度从第二波到第三波都没有下降。
