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动态挑战抑制了最佳的肾配对捐赠的采用:共识会议的结果。

Dynamic challenges inhibiting optimal adoption of kidney paired donation: findings of a consensus conference.

机构信息

Department of Surgery, Stanford University, Stanford, CA.

Department of Internal Medicine, University of Iowa, Iowa City, IA.

出版信息

Am J Transplant. 2013 Apr;13(4):851-860. doi: 10.1111/ajt.12140. Epub 2013 Feb 7.

DOI:10.1111/ajt.12140
PMID:23398969
Abstract

While kidney paired donation (KPD) enables the utilization of living donor kidneys from healthy and willing donors incompatible with their intended recipients, the strategy poses complex challenges that have limited its adoption in United States and Canada. A consensus conference was convened March 29-30, 2012 to address the dynamic challenges and complexities of KPD that inhibit optimal implementation. Stakeholders considered donor evaluation and care, histocompatibility testing, allocation algorithms, financing, geographic challenges and implementation strategies with the goal to safely maximize KPD at every transplant center. Best practices, knowledge gaps and research goals were identified and summarized in this document.

摘要

虽然配对供肾(KPD)可以利用与受者不相容的健康、有意愿的供者的肾脏,但该策略存在复杂的挑战,限制了其在美国和加拿大的应用。为了解决阻碍最佳实施的 KPD 的动态挑战和复杂性,于 2012 年 3 月 29 日至 30 日召开了一次共识会议。利益相关者考虑了供者评估和护理、组织相容性检测、分配算法、融资、地理挑战以及实施策略,目标是在每个移植中心安全地最大限度地提高 KPD。本文档中确定并总结了最佳实践、知识空白和研究目标。

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1
Dynamic challenges inhibiting optimal adoption of kidney paired donation: findings of a consensus conference.动态挑战抑制了最佳的肾配对捐赠的采用:共识会议的结果。
Am J Transplant. 2013 Apr;13(4):851-860. doi: 10.1111/ajt.12140. Epub 2013 Feb 7.
2
Response to "dynamic challenges inhibiting optimal adoption of kidney paired donation: findings of a consensus conference" by Melcher et al.对梅尔彻等人所著《阻碍肾脏配对捐赠最佳应用的动态挑战:共识会议结果》的回应
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Four years of experience with the Australian kidney paired donation programme.澳大利亚肾脏配对捐赠项目的四年经验
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Kidney paired donation: principles, protocols and programs.肾配对捐赠:原则、方案与项目
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Managing highly sensitized renal transplant candidates in the era of kidney paired donation and the new kidney allocation system: Is there still a role for desensitization?在肾匹配捐赠和新的肾脏分配系统时代管理高度致敏的肾移植候选者:脱敏治疗是否仍有作用?
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引用本文的文献

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The Executive Order on Kidney Care: An Opportunity to Improve Outcomes for Individuals With Kidney Disease.关于肾脏护理的行政命令:改善肾病患者治疗效果的契机。
Kidney Int Rep. 2019 Sep 18;4(11):1519-1522. doi: 10.1016/j.ekir.2019.09.011. eCollection 2019 Nov.
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KPDGUI: An interactive application for optimization and management of a virtual kidney paired donation program.KPDGUI:一个用于虚拟肾配对捐赠计划优化和管理的交互式应用程序。
Comput Biol Med. 2019 May;108:345-353. doi: 10.1016/j.compbiomed.2019.03.013. Epub 2019 Mar 16.
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Expanding deceased donor kidney transplantation: medical risk, infectious risk, hepatitis C virus, and HIV.
扩大已故供体肾移植:医学风险、感染风险、丙型肝炎病毒和 HIV。
Curr Opin Nephrol Hypertens. 2018 Nov;27(6):445-453. doi: 10.1097/MNH.0000000000000456.
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Temporal changes in the composition of a large multicenter kidney exchange clearinghouse: Do the hard-to-match accumulate?大型多中心肾脏交换中心组成的时间变化:难以匹配的患者是否会积累?
Am J Transplant. 2018 Nov;18(11):2791-2797. doi: 10.1111/ajt.15046. Epub 2018 Sep 12.
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Kidney exchange match rates in a large multicenter clearinghouse.大型多中心交换中心的肾脏匹配率。
Am J Transplant. 2018 Jun;18(6):1510-1517. doi: 10.1111/ajt.14689. Epub 2018 Mar 9.
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Ethical and Logistical Issues Raised by the Advanced Donation Program "Pay It Forward" Scheme.先进捐赠项目“传递爱心”计划引发的伦理与后勤问题。
J Med Philos. 2017 Oct 1;42(5):518-536. doi: 10.1093/jmp/jhx018.
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KDIGO Clinical Practice Guideline on the Evaluation and Care of Living Kidney Donors.KDIGO 活体肾捐献者评估与管理临床实践指南
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Pregnancy-Induced Sensitization Promotes Sex Disparity in Living Donor Kidney Transplantation.妊娠诱导的致敏作用促进活体供肾移植中的性别差异。
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Utilization of Deceased Donor Kidneys to Initiate Living Donor Chains.利用已故捐赠者的肾脏启动活体捐赠者链式移植。
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A Risk Index for Living Donor Kidney Transplantation.活体供肾移植风险指数
Am J Transplant. 2016 Jul;16(7):2077-84. doi: 10.1111/ajt.13709. Epub 2016 Feb 26.