Nanomedicine and Biomaterial Lab, Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran 1417614411, Iran.
Carbohydr Polym. 2013 Feb 15;92(2):1280-93. doi: 10.1016/j.carbpol.2012.10.036. Epub 2012 Oct 22.
The most considerable challenges facing effective cancer therapy are systemic toxicity of cytotoxic drugs, their lack of tumor localizing and an even distribution throughout the whole body. Besides, short half-lives and undesirable pharmacokinetics are among the other drawbacks that inhibit effective cancer chemotherapy. Conjugation of low molecular weight drugs to polysaccharides has been used as a way to address these problems. This review will focus on polysaccharide drug conjugates and will provide an overview on various conjugation studies which have been accomplished for these carriers with cytotoxic drugs. Although a wide variety of anticancer agents including some toxins have been the subject of conjugation techniques, in this review, low molecular weight cytotoxic drugs conjugated covalently to the carriers are considered.
有效癌症治疗面临的最重大挑战是细胞毒性药物的全身毒性、缺乏肿瘤定位和全身均匀分布。此外，半衰期短和不理想的药代动力学也是抑制有效癌症化疗的其他缺点之一。将低分子量药物与多糖偶联已被用作解决这些问题的一种方法。本综述将重点介绍多糖药物偶联物，并概述已完成的各种与细胞毒性药物偶联的这些载体的偶联研究。尽管已经对包括一些毒素在内的各种抗癌剂进行了偶联技术研究，但在本综述中，考虑了低分子量细胞毒性药物与载体的共价偶联。
