Gobi Ravichandran, Ravichandiran Palanisamy, Babu Ravi Shanker, Yoo Dong Jin
Department of Physics, School of Advanced Sciences, Vellore Institute of Technology, Vellore 632014, India.
R&D Education Center for Whole Life Cycle R&D of Fuel Cell System, Jeonbuk National University, Jeonju 54896, Korea.
Polymers (Basel). 2021 Jun 13;13(12):1962. doi: 10.3390/polym13121962.
Biopolymers are materials obtained from a natural origin, such as plants, animals, microorganisms, or other living beings; they are flexible, elastic, or fibrous materials. Polysaccharides and proteins are some of the natural polymers that are widely used in wound dressing applications. In this review paper, we will provide an overview of biopolymers and synthetic polymer-based nanocomposites, which have promising applications in the biomedical research field, such as wound dressings, wound healing, tissue engineering, drug delivery, and medical implants. Since these polymers have intrinsic biocompatibility, low immunogenicity, non-toxicity, and biodegradable properties, they can be used for various clinical applications. The significant advancements in materials research, drug development, nanotechnology, and biotechnology have laid the foundation for changing the biopolymeric structural and functional properties. The properties of biopolymer and synthetic polymers were modified by blending them with nanoparticles, so that these materials can be used as a wound dressing application. Recent wound care issues, such as tissue repairs, scarless healing, and lost tissue integrity, can be treated with blended polymers. Currently, researchers are focusing on metal/metal oxide nanomaterials such as zinc oxide (ZnO), cerium oxide (CeO), silver (Ag), titanium oxide (TiO), iron oxide (FeO), and other materials (graphene and carbon nanotubes (CNT)). These materials have good antimicrobial properties, as well as action as antibacterial agents. Due to the highly antimicrobial properties of the metal/metal oxide materials, they can be used for wound dressing applications.
生物聚合物是从天然来源获得的材料，如植物、动物、微生物或其他生物；它们是柔性、弹性或纤维状材料。多糖和蛋白质是一些广泛用于伤口敷料应用的天然聚合物。在这篇综述论文中，我们将概述生物聚合物和基于合成聚合物的纳米复合材料，它们在生物医学研究领域有很有前景的应用，如伤口敷料、伤口愈合、组织工程、药物递送和医疗植入物。由于这些聚合物具有固有的生物相容性、低免疫原性、无毒性和可生物降解性，它们可用于各种临床应用。材料研究、药物开发、纳米技术和生物技术的重大进展为改变生物聚合物的结构和功能特性奠定了基础。通过将生物聚合物与纳米颗粒共混来改变其性能，从而使这些材料可用于伤口敷料应用。最近的伤口护理问题，如组织修复、无瘢痕愈合和组织完整性丧失，可用共混聚合物进行治疗。目前，研究人员正专注于金属/金属氧化物纳米材料，如氧化锌（ZnO）、氧化铈（CeO）、银（Ag）、二氧化钛（TiO）、氧化铁（FeO）以及其他材料（石墨烯和碳纳米管（CNT））。这些材料具有良好的抗菌性能，可作为抗菌剂发挥作用。由于金属/金属氧化物材料具有高度抗菌性能，它们可用于伤口敷料应用。
