School of Food Science and Technology, Jiangnan University, 1800 Lihu AVE, Wuxi 214122, People's Republic of China.
Carbohydr Polym. 2013 Feb 15;92(2):1633-40. doi: 10.1016/j.carbpol.2012.11.037. Epub 2012 Nov 23.
Food grade biopolymers, such as dextrin, have been suggested as a technological solution for the controlled delivery of health promoting substances. The main focus of this work is to improve the stability of poly-unsaturated fatty acids (PUFAs) and controlled release by encapsulating with helical spring dextrin (SD). The encapsulation was formed between SD with a DP¯ of 62 and α-linolenic acid (ALA) or linoleic acid (LA) at 60 °C and characterized by WXRD, DSC, TGA and SEM. Under conditions which simulated the human environment of the gastrointestinal system, 21.7% and 18.5% of SD-ALA and SD-LA were released, respectively. A molecular dynamics simulation indicated that the space of helix cavity for ALA-SD complex was larger than that for LA-SD complex. This research work supports the idea that these complexes not only can improve the stability of ALA and LA, but also can achieve the targeted delivery of functional lipids or other bioactive components to the small intestine.
食品级生物聚合物，如糊精，已被提议作为一种控制传递促进健康物质的技术解决方案。这项工作的主要重点是通过用螺旋弹簧糊精（SD）包埋来提高多不饱和脂肪酸（PUFAs）的稳定性和控制释放。在 60°C 下，将 DP¯为 62 的 SD 与α-亚麻酸（ALA）或亚油酸（LA）之间形成包埋，并通过 WXRD、DSC、TGA 和 SEM 进行表征。在模拟人体胃肠道环境的条件下，分别释放了 21.7%和 18.5%的 SD-ALA 和 SD-LA。分子动力学模拟表明，ALA-SD 配合物的螺旋腔空间大于 LA-SD 配合物的空间。这项研究工作支持这样一种观点，即这些配合物不仅可以提高 ALA 和 LA 的稳定性，而且可以实现将功能性脂质或其他生物活性成分靶向递送到小肠。
