Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala 147002, Punjab, India.
Carbohydr Polym. 2013 Feb 15;92(2):1660-8. doi: 10.1016/j.carbpol.2012.11.032. Epub 2012 Nov 19.
The present investigation was aimed at optimizing the conditions for preparing sulfated derivative of gum obtained from partially ripe fruits of Aegle marmelos. Elemental analysis, FTIR-ATR and NMR studies confirmed successful sulfation. The ratio of chlorosulfonic acid to pyridine exerted maximum influence on the degree of substitution followed by reaction temperature and reaction time. The sulfated derivative showed higher swelling in both acidic and alkaline pH as compared to unmodified gum. It also possessed higher negative zeta potential, higher viscosity, work of shear, firmness, consistency, cohesiveness and index of viscosity as compared to both unmodified gum as well as sodium alginate. Sulfated derivative was superior to unmodified gum and sodium alginate in terms of antimicrobial and anticoagulant activity. The sulfated sample appears to be a potential substitute over the unmodified gum sample and sodium alginate for modulating physicochemical properties of food and drug release dosage forms.
本研究旨在优化从部分成熟的酸橙果实中提取的胶的硫酸化衍生物的制备条件。元素分析、FTIR-ATR 和 NMR 研究证实了成功的硫酸化。氯磺酸与吡啶的比例对取代度的影响最大，其次是反应温度和反应时间。与未改性胶相比，硫酸化衍生物在酸性和碱性 pH 值下具有更高的溶胀性。与未改性胶和海藻酸钠相比，它还具有更高的负 ζ 电位、更高的粘度、剪切功、硬度、稠度、内聚性和粘度指数。硫酸化衍生物在抗菌和抗凝血活性方面优于未改性胶和海藻酸钠。就调节食品的物理化学性质和药物释放剂型的药物释放而言，硫酸化样品似乎是未改性胶样品和海藻酸钠的潜在替代品。
