Sciubba James J, Helman Joseph I
Department of Otolaryngology-Head and Neck Surgery, The Johns Hopkins Hospital, 600 North Wolfe Street, Sheikh Zayed Tower, Baltimore, MD 21287, USA.
Oral Maxillofac Surg Clin North Am. 2013 Feb;25(1):77-82, vi. doi: 10.1016/j.coms.2012.11.008.
Proliferative verrucous leukoplakia, a lesion of unknown origin with no strictly defined diagnostic criteria, is worthy of great clinical concern and scrutiny. Treatment options vary, with no consensus regarding the most efficient and effective strategy. Further complicating the unusual biology and behavior of this lesion is its usual multifocal presentation and progression, with lifelong vigilance required after treatment. Verrucous carcinoma is a progressive lesion with high recurrence and 5-year survival rates. Surgery remains the preferred treatment. Further investigation into the combination of surgery and antiviral agents may bring additional improvement in patient care.
增殖性疣状白斑是一种病因不明且无严格定义诊断标准的病变，值得临床高度关注和仔细检查。治疗方案各异，对于最有效策略尚无共识。该病变不寻常的生物学特性和行为使其多灶性表现及进展情况更为复杂，治疗后需要终身保持警惕。疣状癌是一种具有高复发率和5年生存率的进行性病变。手术仍是首选治疗方法。对手术与抗病毒药物联合使用的进一步研究可能会给患者护理带来更多改善。
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