Bang Kshitij, Shenoi Ramakrishna, Kolte Vrinda, Jadhav Karishma D, Malikar Hrushikesh K
Oral and Maxillofacial Surgery, VSPM's Dental College and Research Centre, Nagpur, IND.
Cureus. 2025 Mar 16;17(3):e80645. doi: 10.7759/cureus.80645. eCollection 2025 Mar.
Verrucous carcinoma (VC) is an uncommon, well-differentiated variant of squamous cell carcinoma (SCC) with a locally aggressive yet non-metastatic nature. It primarily affects the oral cavity, particularly the buccal mucosa, lips, and hard palate. Clinically, it presents as an exophytic, warty, or cauliflower-like lesion that can be misdiagnosed due to its resemblance to non-neoplastic ulcerative conditions. Histopathologically, VC exhibits pronounced keratinization, hyperplastic epithelium, and a test-tube-like growth pattern without significant nuclear atypia or metastasis. This case report describes a 41-year-old male presenting with a persistent ulcero-proliferative lesion diagnosed as VC. Surgical management included wide local excision, supra-omohyoid neck dissection, and partial maxillectomy with marginal mandibulectomy, utilizing a lower lip split apron flap for optimal access and minimal scarring. The defect was reconstructed with an anterolateral thigh (ALT) flap. The case highlights the necessity for precise diagnosis, an interdisciplinary approach, and the importance of surgical strategies to achieve optimal treatment outcomes in VC patients.
疣状癌（VC）是一种罕见的、高分化的鳞状细胞癌（SCC）变体，具有局部侵袭性但无转移特性。它主要累及口腔，尤其是颊黏膜、唇部和硬腭。临床上，它表现为外生性、疣状或菜花状病变，因其与非肿瘤性溃疡性疾病相似，可能会被误诊。组织病理学上，VC表现为明显的角化、上皮增生以及试管样生长模式，无明显核异型性或转移。本病例报告描述了一名41岁男性，患有持续性溃疡增生性病变，诊断为VC。手术治疗包括广泛局部切除、肩胛舌骨肌上颈部清扫术以及部分上颌骨切除术加边缘性下颌骨切除术，采用下唇劈开围裙瓣以获得最佳术野并减少瘢痕。缺损用股前外侧（ALT）皮瓣修复。该病例强调了精确诊断的必要性、多学科方法以及手术策略对于实现VC患者最佳治疗效果的重要性。
