Department of Pharmaceutics, Gupta College of Technological Sciences, Asansol, WB, India.
Colloids Surf B Biointerfaces. 2013 May 1;105:303-9. doi: 10.1016/j.colsurfb.2013.01.013. Epub 2013 Jan 16.
The present work deals with the preparation, characterization and evaluation of glutaraldehyde cross-linked chitosan-tamarind seed polysaccharide (TSP) interpenetrating polymeric network (IPN) microparticles for prolonged aceclofenac release. The drug entrapment efficiency of these microparticles was found 85.84±1.75 to 91.97±1.30% and their average particle sizes were ranged from 490.55±23.24 to 621.60±53.57 μm. These chitosan-TSP IPN microparticles were characterized by FTIR, DSC, and SEM analyses. The in vitro drug release from these aceclofenac-loaded chitosan-TSP IPN microparticles showed sustained release of aceclofenac over 8h and followed the Korsmeyer-Peppas model (R(2)=0.9809-0.9828) with anomalous (non-Fickian) diffusion drug release mechanism. The in vivo studies exhibited sustained anti-inflammatory activity in carrageenan-induced rats over prolonged period after oral administration of these newly developed aceclofenac-loaded IPN microparticles.
本工作涉及制备、表征和评价戊二醛交联壳聚糖-罗望子种子多糖（TSP）互穿聚合物网络（IPN）微球，用于延长醋氯芬酸的释放。这些微球的药物包封效率为 85.84±1.75%至 91.97±1.30%，平均粒径为 490.55±23.24μm 至 621.60±53.57μm。这些壳聚糖-TSP IPN 微球通过傅里叶变换红外光谱（FTIR）、差示扫描量热法（DSC）和扫描电子显微镜（SEM）进行了表征。这些载醋氯芬酸的壳聚糖-TSP IPN 微球的体外药物释放显示出醋氯芬酸的持续释放超过 8 小时，并遵循 Korsmeyer-Peppas 模型（R(2)=0.9809-0.9828），具有异常（非菲克）扩散药物释放机制。体内研究表明，这些新开发的载醋氯芬酸 IPN 微球口服给药后，在延长的时间内可在角叉菜胶诱导的大鼠中持续发挥抗炎活性。
