Chyzy Adam, Tomczykowa Monika, Plonska-Brzezinska Marta E
Department of Organic Chemistry, Faculty of Pharmacy with the Division of Laboratory Medicine, Medical University of Bialystok, Mickiewicza 2A, 15-222 Bialystok, Poland.
Materials (Basel). 2020 Jan 2;13(1):188. doi: 10.3390/ma13010188.
This review is an extensive evaluation and essential analysis of the design and formation of hydrogels (HGs) for drug delivery. We review the fundamental principles of HGs (their chemical structures, physicochemical properties, synthesis routes, different types, etc.) that influence their biological properties and medical and pharmaceutical applications. Strategies for fabricating HGs with different diameters (macro, micro, and nano) are also presented. The size of biocompatible HG materials determines their potential uses in medicine as drug carriers. Additionally, novel drug delivery methods for enhancing treatment are discussed. A critical review is performed based on the latest literature reports.
本综述是对用于药物递送的水凝胶（HG）的设计与形成进行的广泛评估和重要分析。我们回顾了影响水凝胶生物学特性以及医学和制药应用的基本原理（其化学结构、物理化学性质、合成路线、不同类型等）。还介绍了制备不同直径（宏观、微观和纳米）水凝胶的策略。生物相容性水凝胶材料的尺寸决定了它们作为药物载体在医学中的潜在用途。此外，还讨论了用于增强治疗效果的新型药物递送方法。基于最新的文献报道进行了批判性综述。
