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Neurodegenerative disease: altered DNA methylation and RNA splicing could be key mechanisms in Huntington disease.

作者信息

Wood Heather

出版信息

Nat Rev Neurol. 2013 Mar;9(3):119. doi: 10.1038/nrneurol.2013.23. Epub 2013 Feb 12.

DOI:10.1038/nrneurol.2013.23
PMID:23399643
Abstract
摘要

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1
Neurodegenerative disease: altered DNA methylation and RNA splicing could be key mechanisms in Huntington disease.神经退行性疾病:DNA甲基化和RNA剪接改变可能是亨廷顿病的关键机制。
Nat Rev Neurol. 2013 Mar;9(3):119. doi: 10.1038/nrneurol.2013.23. Epub 2013 Feb 12.
2
Extensive changes in DNA methylation are associated with expression of mutant huntingtin.广泛的 DNA 甲基化变化与突变 huntingtin 的表达有关。
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3
The long and the short of aberrant ciliogenesis in Huntington disease.亨廷顿病中纤毛异常发生的长与短。
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4
Changes in the store-dependent calcium influx in a cellular model of Huntington's disease.亨廷顿舞蹈症细胞模型中储存依赖性钙内流的变化
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Progress and challenges in RNA interference therapy for Huntington disease.亨廷顿舞蹈症RNA干扰疗法的进展与挑战
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6
Ciliogenesis is regulated by a huntingtin-HAP1-PCM1 pathway and is altered in Huntington disease.纤毛发生受亨廷顿蛋白-HAP1-PCM1 途径调控,并在亨廷顿病中发生改变。
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7
Paradoxical aggregation versus oligomerisation properties of mutant and wild-type huntingtin fragments.突变型和野生型亨廷顿蛋白片段的反常聚集与寡聚化特性
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Potent and selective antisense oligonucleotides targeting single-nucleotide polymorphisms in the Huntington disease gene / allele-specific silencing of mutant huntingtin.针对亨廷顿病基因中单核苷酸多态性的有效且选择性的反义寡核苷酸/突变亨廷顿蛋白的等位基因特异性沉默。
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Interacting proteins as genetic modifiers of Huntington disease.相互作用蛋白作为亨廷顿病的基因修饰因子
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Normal and mutant huntingtin: partners in crime.正常亨廷顿蛋白与突变亨廷顿蛋白:犯罪同伙。
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Inflammopharmacology. 2024 Jun;32(3):1791-1804. doi: 10.1007/s10787-024-01477-0. Epub 2024 Apr 23.
2
DNA methylation of microRNA-365-1 induces apoptosis of hair follicle stem cells by targeting .微小RNA-365-1的DNA甲基化通过靶向……诱导毛囊干细胞凋亡。
Noncoding RNA Res. 2024 Mar 11;9(3):901-912. doi: 10.1016/j.ncrna.2024.03.001. eCollection 2024 Sep.
3
Role of DNMTs in the Brain.

本文引用的文献

1
Extensive changes in DNA methylation are associated with expression of mutant huntingtin.广泛的 DNA 甲基化变化与突变 huntingtin 的表达有关。
Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2354-9. doi: 10.1073/pnas.1221292110. Epub 2013 Jan 22.
2
Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease.亨廷顿病中 HTT 的异常剪接导致致病外显子 1 蛋白的产生。
Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2366-70. doi: 10.1073/pnas.1221891110. Epub 2013 Jan 22.
3
A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's Disease Collaborative Research Group.
DNA甲基转移酶在大脑中的作用。
Adv Exp Med Biol. 2022;1389:363-394. doi: 10.1007/978-3-031-11454-0_15.
4
DNA Methylation: A Promising Approach in Management of Alzheimer's Disease and Other Neurodegenerative Disorders.DNA甲基化:阿尔茨海默病及其他神经退行性疾病治疗中的一种有前景的方法。
Biology (Basel). 2022 Jan 7;11(1):90. doi: 10.3390/biology11010090.
5
Epigenomic Remodeling in Huntington's Disease-Master or Servant?亨廷顿舞蹈病中的表观基因组重塑:主因还是从属因素?
Epigenomes. 2020 Jul 31;4(3):15. doi: 10.3390/epigenomes4030015.
6
Axonal Degeneration during Aging and Its Functional Role in Neurodegenerative Disorders.衰老过程中的轴突退化及其在神经退行性疾病中的功能作用。
Front Neurosci. 2017 Sep 4;11:451. doi: 10.3389/fnins.2017.00451. eCollection 2017.
7
DNA methylation age-acceleration is associated with disease duration and age at onset in C9orf72 patients.DNA 甲基化年龄加速与 C9orf72 患者的疾病持续时间和发病年龄有关。
Acta Neuropathol. 2017 Aug;134(2):271-279. doi: 10.1007/s00401-017-1713-y. Epub 2017 Apr 24.
8
The epigenetics of aging and neurodegeneration.衰老与神经退行性变的表观遗传学
Prog Neurobiol. 2015 Aug;131:21-64. doi: 10.1016/j.pneurobio.2015.05.002. Epub 2015 Jun 11.
9
Epigenetic mechanisms of neurodegeneration in Huntington's disease.亨廷顿病中神经退行性变的表观遗传机制。
Neurotherapeutics. 2013 Oct;10(4):664-76. doi: 10.1007/s13311-013-0206-5.
一个含有三核苷酸重复序列的新基因,该序列在亨廷顿病染色体上呈扩增且不稳定状态。亨廷顿病协作研究组。
Cell. 1993 Mar 26;72(6):971-83. doi: 10.1016/0092-8674(93)90585-e.