C,N-环 N'-酰基腙亚胺、异氰化物和叠氮化合物的三组分反应：有效合成具有四氢异喹啉骨架的 1,5-取代四唑
A three-component reaction of C,N-cyclic N'-acyl azomethine imines, isocyanides, and azide compounds: effective synthesis of 1,5-disubstituted tetrazoles with tetrahydroisoquinoline skeletons.
机构信息
Division of Material Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma, Kanazawa 920-1192, Japan.
出版信息
Org Biomol Chem. 2013 Apr 7;11(13):2168-74. doi: 10.1039/c3ob27297d.
PMID:23400314
Abstract
A multicomponent reaction of isocyanides and C,N-cyclic N'-acyl azomethine imines in the presence of TMSCl and NaN3 leads to tetrazole derivatives. These reactions proceeded cleanly to afford the corresponding 1,5-disubstituted tetrazoles containing a tetrahydroisoquinoline skeleton in high to excellent yields.
摘要
异氰化物和 C，N-环 N'-酰基偶氮甲脒亚胺在 TMSCl 和NaN3 的存在下的多组分反应导致四唑衍生物的形成。这些反应干净地进行，以高至优异的收率得到含有四氢异喹啉骨架的相应的 1,5-二取代四唑。
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