Division of Material Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma, Kanazawa 920-1192, Japan.
Org Lett. 2012 Mar 2;14(5):1226-9. doi: 10.1021/ol2034542. Epub 2012 Feb 10.
A catalyst-free [5 + 1] cycloaddition reaction between isocyanides and C,N-cyclic N'-acyl azomethine imines as the "isocyanophile" leading to novel heterocycles has been developed. These reactions proceeded quickly and cleanly to afford the corresponding imin-1,3,4-oxadiazin-6-one derivatives in high to excellent yields. A wide range of C,N-cyclic N'-acyl azomethine imines and isocyanides were applicable to this reaction.
一种无催化剂的[5 + 1]环加成反应，其中异氰化物和 C，N-环状 N'-酰基亚胺亚胺作为“异氰亲核试剂”，导致新型杂环的形成。这些反应快速而干净地进行，以高至优异的收率得到相应的亚氨基-1,3,4-噁二嗪-6-酮衍生物。广泛的 C，N-环状 N'-酰基亚胺亚胺和异氰化物都适用于该反应。
