利用分子内炔烃氢肼化方法合成亚胺腙。

Synthesis of azomethine imines using an intramolecular alkyne hydrohydrazination approach.

机构信息

Centre for Catalysis Research and Innovation, Department of Chemistry, University of Ottawa, 10 Marie-Curie, Ottawa, ON, K1N 6N5, Canada.

出版信息

J Org Chem. 2013 Sep 6;78(17):8847-52. doi: 10.1021/jo4011409. Epub 2013 Aug 15.

DOI:10.1021/jo4011409

PMID:23895439

Abstract

Azomethine imines can be accessed upon heating appropriate alkynylhydrazide precursors. This simple thermal hydroamination approach allows the formation of five- and six-membered dipoles in modest to excellent yields. The structure of the acyl group is important to minimize side reactions and allow the isolation of the azomethine imines by column chromatography.

摘要

亚甲胺叶立德可以通过加热适当的炔基腙前体来制备。这种简单的热氢胺化方法可以在中等至优异的收率下形成五元和六元偶极子。酰基的结构对于减少副反应并通过柱色谱法分离亚甲胺叶立德很重要。