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桥小脑角和内听道的脂肪瘤:首要原则是不造成伤害。

Lipomas of the cerebellopontine angle and internal auditory canal: Primum Non Nocere.

机构信息

Department of Otolaryngology-Head and Neck Surgery, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA.

出版信息

Laryngoscope. 2013 Jun;123(6):1531-6. doi: 10.1002/lary.23882. Epub 2013 Feb 9.

Abstract

OBJECTIVES/HYPOTHESIS: To describe the presentation and clinical course of cerebellopontine angle (CPA) and internal auditory canal (IAC) lipomas.

STUDY DESIGN

Retrospective cohort study at a tertiary academic referral center.

METHODS

All patients presenting with a CPA or IAC mass radiographically consistent with a lipoma on high-resolution magnetic resonance imaging (MRI) were identified. Data including presenting symptomatology, tumor characteristics, management strategy, and patient course were collected.

RESULTS

Between 1996 and 2012, 15 patients were diagnosed with a CPA or IAC lipoma at the authors' institution and were included in the analysis. The mean duration of radiological and clinical follow-up was 3.4 years and 5.1 years, respectively. Eight lesions were confined to the IAC, while seven involved the CPA. The median tumor size at diagnosis was 7.2 mm; one patient demonstrated tumor growth on serial MRI while the remaining subjects did not have radiological progression. The most common presenting symptoms were sensorineural hearing loss (40%) and tinnitus (33%); five patients were diagnosed after incidental discovery on MRI. Fourteen patients were managed with observation, while one subject underwent subtotal resection. None of the observed patients reported worsening symptoms at last follow-up.

CONCLUSIONS

While rare, lipomas should be included in the differential diagnosis of CPA and IAC lesions. Owing to a generally benign clinical course and high morbidity associated with resection, microsurgery should only be considered in cases of definite tumor enlargement with intractable symptoms from mass effect. Careful radiological evaluation is critical for establishing an accurate diagnosis in order to prevent unnecessary morbidity associated with resection.

摘要

目的/假设:描述桥小脑角(CPA)和内听道(IAC)脂肪瘤的表现和临床过程。

研究设计

在三级学术转诊中心进行的回顾性队列研究。

方法

所有在高分辨率磁共振成像(MRI)上显示与脂肪瘤一致的 CPA 或 IAC 肿块的患者均被确定。收集的数据包括表现症状、肿瘤特征、管理策略和患者病程。

结果

1996 年至 2012 年期间,作者所在机构诊断出 15 例 CPA 或 IAC 脂肪瘤患者,将其纳入分析。影像学和临床随访的平均时间分别为 3.4 年和 5.1 年。8 个病变局限于 IAC,7 个病变累及 CPA。诊断时肿瘤大小中位数为 7.2mm;1 例患者在连续 MRI 上显示肿瘤生长,其余患者无影像学进展。最常见的表现症状是感音神经性听力损失(40%)和耳鸣(33%);5 例患者在 MRI 偶然发现后诊断。14 例患者接受观察治疗,1 例患者接受次全切除术。在最后一次随访时,没有观察到患者的症状恶化。

结论

尽管罕见,但脂肪瘤应纳入 CPA 和 IAC 病变的鉴别诊断。由于手术切除相关的发病率高,且临床过程通常为良性,因此只有在肿瘤明显增大且肿块效应引起的症状无法控制时,才应考虑显微手术。仔细的影像学评估对于做出准确诊断至关重要,以防止与手术切除相关的不必要的发病率。

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