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BMC Vet Res. 2011 Oct 21;7:62. doi: 10.1186/1746-6148-7-62.
2
Post-menopausal hormone therapy reduces autoantibodies to oxidized apolipoprotein B100.绝经后激素治疗可降低对氧化载脂蛋白 B100 的自身抗体。
Gynecol Endocrinol. 2011 Oct;27(10):800-6. doi: 10.3109/09513590.2010.526660. Epub 2011 Aug 31.
3
Immunoproteomics of HER2-positive and HER2-negative breast cancer patients with positive lymph nodes.HER2 阳性和 HER2 阴性伴阳性淋巴结乳腺癌患者的免疫蛋白质组学。
OMICS. 2011 Jun;15(6):409-18. doi: 10.1089/omi.2010.0131. Epub 2011 May 13.
4
Amphiregulin mediates estrogen, progesterone, and EGFR signaling in the normal rat mammary gland and in hormone-dependent rat mammary cancers. Amphiregulin 介导雌激素、孕激素和 EGFR 信号在正常大鼠乳腺和激素依赖性大鼠乳腺癌中的作用。
Horm Cancer. 2010 Oct;1(5):229-44. doi: 10.1007/s12672-010-0048-0. Epub 2010 Nov 23.
5
An experimental strategy for quantitative analysis of the humoral immune response to prostate cancer antigens using natural protein microarrays.使用天然蛋白质微阵列定量分析前列腺癌抗原体液免疫反应的实验策略。
Proteomics Clin Appl. 2007 May;1(5):494-505. doi: 10.1002/prca.200600802. Epub 2007 Apr 19.
6
Confounding effects of hormone replacement therapy in protein biomarker studies.激素替代疗法对蛋白质生物标志物研究的混杂影响。
Cancer Epidemiol Biomarkers Prev. 2011 Jan;20(1):134-9. doi: 10.1158/1055-9965.EPI-10-0673. Epub 2010 Oct 29.
7
Postmenopausal estrogen and progestin effects on the serum proteome.绝经后雌激素和孕激素对血清蛋白质组的影响。
Genome Med. 2009 Dec 24;1(12):121. doi: 10.1186/gm121.
8
Integrated proteomic analysis of human cancer cells and plasma from tumor bearing mice for ovarian cancer biomarker discovery.荷瘤小鼠人源癌细胞和血浆的整合蛋白质组分析用于卵巢癌生物标志物的发现。
PLoS One. 2009 Nov 19;4(11):e7916. doi: 10.1371/journal.pone.0007916.
9
Increased expression of enolase alpha in human breast cancer confers tamoxifen resistance in human breast cancer cells.烯醇化酶α在人乳腺癌中的高表达赋予人乳腺癌细胞对他莫昔芬的耐药性。
Breast Cancer Res Treat. 2010 Jun;121(3):539-53. doi: 10.1007/s10549-009-0492-0. Epub 2009 Aug 5.
10
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乳腺癌抗原自身免疫反应的蛋白质组学分析揭示了激素治疗的抑制作用。

Proteomic profiling of the autoimmune response to breast cancer antigens uncovers a suppressive effect of hormone therapy.

机构信息

Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.

出版信息

Proteomics Clin Appl. 2013 Jun;7(5-6):327-36. doi: 10.1002/prca.201200058. Epub 2013 May 10.

DOI:10.1002/prca.201200058
PMID:23401414
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4681300/
Abstract

PURPOSE

Proteomics technologies are well suited for harnessing the immune response to tumor antigens for diagnostic applications as in the case of breast cancer. We previously reported a substantial impact of hormone therapy (HT) on the proteome. Here, we investigated the effect of HT on the immune response toward breast tumor antigens.

EXPERIMENTAL DESIGN

Plasmas collected 0-10 months prior to diagnosis of ER+ breast cancer from 190 postmenopausal women and 190 controls that participated in the Women's Health Initiative Observational Study were analyzed for the effect of HT on IgG reactivity against arrayed proteins from MCF-7 or SKBR3 breast cancer cell line lysates following extensive fractionation.

RESULTS

HT user cases exhibited significantly reduced autoantibody reactivity against arrayed proteins compared to cases who were Not Current users. An associated reduced level of IL-6 and other immune-related cytokines was observed among HT users relative to nonusers.

CONCLUSION AND CLINICAL RELEVANCE

Our findings suggest occurrence of a global altered immune response to breast cancer-derived proteins associated with HT. Thus a full understanding of factors that modulate the immune response is necessary to translate autoantibody panels into clinical applications.

摘要

目的

蛋白质组学技术非常适合利用针对肿瘤抗原的免疫反应进行诊断应用，如乳腺癌。我们之前曾报道过激素治疗（HT）对蛋白质组的重大影响。在这里，我们研究了 HT 对针对乳腺肿瘤抗原的免疫反应的影响。

实验设计

从参加妇女健康倡议观察研究的 190 名绝经后妇女和 190 名对照者中，收集了在诊断为 ER+乳腺癌前 0-10 个月的血浆，并对其进行了分析，以了解 HT 对 MCF-7 或 SKBR3 乳腺癌细胞系裂解物的阵列蛋白的 IgG 反应性的影响，这些蛋白经过了广泛的分级分离。

结果

与未使用 HT 的患者相比，HT 使用病例的针对阵列蛋白的自身抗体反应性显著降低。与未使用者相比，HT 使用者中观察到 IL-6 和其他免疫相关细胞因子的水平降低。

结论和临床相关性

我们的研究结果表明，HT 与乳腺癌相关蛋白的免疫反应发生了普遍改变。因此，有必要全面了解调节免疫反应的因素，以将自身抗体面板转化为临床应用。