Petsios Konstantinos Th, Priftis Kostas N, Hatziagorou Elpis, Tsanakas John N, Antonogeorgos George, Matziou Vasiliki N
Pediatric Cardiosurgical Intensive Care Unit, "Onassis" Cardiac Surgery Center, Athens, Greece; Faculty of Nursing, National & Kapodistrian University of Athens, Athens, Greece.
Pediatr Pulmonol. 2013 Dec;48(12):1171-80. doi: 10.1002/ppul.22768. Epub 2013 Feb 8.
HRQoL in children with asthma depends on multiple factors, among which asthma severity and level of control are believed to play a vital role. The determinants of the connection between asthma severity and asthma control with quality of life remain unclear.
Primary aim of the study was to evaluate the HRQoL in children with asthma and to determine the factors that affect it.
In total 504 children and one of their parents were recruited during a regular follow up visit in an outpatient asthma clinic. The measures used were the DISABKIDS smiley measure (DSmM), chronic generic measure-long form (DCGM-37) and the Condition-specific modules for asthma along with a special form for collecting demographic and clinical characteristics.
Three hundred fifteen children with mean age 5.35 years (Group A) and 189 with mean age 10.79 years (Group B), were recruited. Children with controlled asthma had significant higher mean score than the other asthma control groups (P < 0.001). Corticosteroid use, asthma severity, number of visits in doctor's office and lack of asthma control were significantly associated with the DCGM-37 scores as well as Impact Scale and Worry Scale. Lack of Asthma Control was the only factor that was associated with negative HRQoL in all the multiple regression models, controlling for the effect of the other covariates, in both age groups.
In conclusion, the evaluation of asthma HRQoL independently reflects the asthma control state and a dimension of its severity. These results highlight the need to modify asthma management strategy.
哮喘患儿的健康相关生活质量（HRQoL）取决于多种因素，其中哮喘严重程度和控制水平被认为起着至关重要的作用。哮喘严重程度与哮喘控制和生活质量之间联系的决定因素仍不清楚。
本研究的主要目的是评估哮喘患儿的HRQoL，并确定影响其的因素。
在一家门诊哮喘诊所的定期随访中，共招募了504名儿童及其一名家长。所使用的测量方法包括残疾儿童笑脸量表（DSmM）、慢性通用量表长版（DCGM - 37）以及哮喘特定情况模块，同时还有一份用于收集人口统计学和临床特征的特殊表格。
招募了平均年龄5.35岁的315名儿童（A组）和平均年龄10.79岁的189名儿童（B组）。哮喘得到控制的儿童的平均得分显著高于其他哮喘控制组（P < 0.001）。使用皮质类固醇、哮喘严重程度、到医生办公室就诊的次数以及哮喘控制不佳与DCGM - 37得分以及影响量表和担忧量表显著相关。在控制了其他协变量影响的所有多元回归模型中，哮喘控制不佳是两个年龄组中与不良HRQoL相关的唯一因素。
总之，哮喘HRQoL的评估独立反映了哮喘控制状态及其严重程度的一个维度。这些结果凸显了修改哮喘管理策略的必要性。
