Department of Medical Oncology, Zhejiang Cancer Hospital, HangZhou, 310022, China.
Anat Rec (Hoboken). 2013 Apr;296(4):604-10. doi: 10.1002/ar.22661. Epub 2013 Feb 9.
Pancreatic cancer is one of the most lethal human malignancies with a very low 5-year survival rate, which highlights urgent needs for more effective therapeutic strategies. In this study, we examined the potential therapeutic effects of an adenovirus encoding human interferon gamma (Ad-IFNγ) on pancreatic carcinoma cells Capan-2 in vitro and in vivo. The results indicated that Ad-IFNγ could significantly inhibit tumor cell growth via inducing cell apoptosis. After infection, IFNγ expressed durably and stably in xenografts, predominantly in tumor tissue, while much less in blood and liver. Thus, adenovirus-mediated intratumoral injection of human IFNγ gene could be an effective gene therapeutic system for the treatment of pancreatic carcinoma.
胰腺癌是人类恶性程度最高的肿瘤之一，5 年生存率极低，这突显了对更有效治疗策略的迫切需求。在这项研究中，我们研究了编码人干扰素 γ 的腺病毒（Ad-IFNγ）对体外和体内胰腺癌细胞 Capan-2 的潜在治疗效果。结果表明，Ad-IFNγ 可通过诱导细胞凋亡显著抑制肿瘤细胞生长。感染后，IFNγ 在异种移植物中持续且稳定地表达，主要在肿瘤组织中，而在血液和肝脏中则较少。因此，腺病毒介导的人 IFNγ 基因瘤内注射可能是治疗胰腺癌的有效基因治疗系统。
