Hepatic branch vagotomy attenuates the feeding response to 2-deoxy-D-glucose in rats.

The effect of hepatic branch vagotomy on the feeding response induced in rats by intraperitoneally injected 2-deoxy-D-glucose (2-DG) was tested. Injections were given 1 h after onset of the dark phase, and immediately [corrected] after the rats had ingested a meal. 2-DG produced a smaller feeding response in hepatic branch-vagotomized rats compared with that in sham-vagotomized rats. This finding suggests that hepatic glucoreceptors with vagal afferent fibres are involved in the feeding response to glucose deprivation.