年龄和肝支迷走神经切断术对大鼠食物摄入量昼夜分布的影响。

Influence of age and hepatic branch vagotomy on the night/day distribution of food intake in rats.

作者信息

Del Prete E, Scharrer E

机构信息

Institute of Veterinary Physiology, University of Zurich, Switzerland.

出版信息

Z Ernahrungswiss. 1993 Dec;32(4):316-20. doi: 10.1007/BF01611170.

DOI:10.1007/BF01611170

PMID:8128753

Abstract

The aim of the present study was to investigate the influence of age and hepatic branch vagotomy on the night/day distribution of food intake in male rats. Food intake of young (age: 2 months) and aged (age: 13.5 months) hepatic branch vagotomized (HBV) and sham-vagotomized (SV) rats was measured at intervals of 6 h during the 12 h dark and the 12 h light phase. The results show that in rats the night/day ratio of food intake decreases with age and is not affected by hepatic branch vagotomy. However, the time-course of spontaneous diurnal food intake was influenced by hepatic branch vagotomy. The change in the night/day distribution of food intake might be due to age-related changes in the nucleus suprachiasmaticus of the hypothalamus.

摘要

本研究的目的是探讨年龄和肝支迷走神经切断术对雄性大鼠食物摄入昼夜分布的影响。在12小时黑暗期和12小时光照期，每隔6小时测量年轻（年龄：2个月）和老年（年龄：13.5个月）肝支迷走神经切断术（HBV）和假迷走神经切断术（SV）大鼠的食物摄入量。结果表明，大鼠的食物摄入昼夜比随年龄下降，且不受肝支迷走神经切断术影响。然而，肝支迷走神经切断术影响了自发性昼夜食物摄入的时间进程。食物摄入昼夜分布的变化可能归因于下丘脑视交叉上核的年龄相关变化。