肿瘤氧合、再氧合及其对治疗结果的影响建模。
Modelling tumour oxygenation, reoxygenation and implications on treatment outcome.
机构信息
Medical Radiation Physics, Stockholm University and Karolinska Institutet, 171 76 Stockholm, Sweden.
出版信息
Comput Math Methods Med. 2013;2013:141087. doi: 10.1155/2013/141087. Epub 2013 Jan 14.
Abstract
Oxygenation is an important component of the tumour microenvironment, having a significant impact on the progression and management of cancer. Theoretical determination of tissue oxygenation through simulations of the oxygen transport process is a powerful tool to characterise the spatial distribution of oxygen on the microscopic scale and its dynamics and to study its impact on the response to radiation. Accurate modelling of tumour oxygenation must take into account important aspects that are specific to tumours, making the quantitative characterisation of oxygenation rather difficult. This paper aims to discuss the important aspects of modelling tumour oxygenation, reoxygenation, and implications for treatment.
摘要
氧合作用是肿瘤微环境的一个重要组成部分，对癌症的发展和治疗有重大影响。通过模拟氧气传输过程来理论上确定组织氧合作用是一种强大的工具，可以描述微观尺度上氧气的空间分布及其动态，并研究其对放射治疗反应的影响。准确地模拟肿瘤氧合作用必须考虑到肿瘤特有的重要方面，这使得氧合作用的定量描述变得相当困难。本文旨在讨论肿瘤氧合作用、再氧合作用的建模的重要方面及其对治疗的影响。
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