Kakos Lynn Reese, Alosco Michael L, Spitznagel Mary Beth, Hughes Joel, Rosneck Jim, Gunstad John
Department of Psychology, Kent State University, Kent, OH 44242, USA.
Cardiovasc Psychiatry Neurol. 2013;2013:659589. doi: 10.1155/2013/659589. Epub 2013 Jan 21.
Background. Psychiatric comorbidity is common in patients with cardiovascular disease, with the literature indicating that this population may be at risk for apathy. The current study examined the prevalence of apathy in patients with cardiovascular disease and its relation to aspects of cognitive function. Methods. 123 participants from an outpatient cardiology clinic completed a brief neuropsychological battery, a cardiac stress test, and demographic information, medical history, and depression symptomatology self-report measures. Participants also completed the Apathy Evaluation Scale to quantify apathy. Results. These subjects reported limited levels of apathy and depression. Increased depressive symptomatology, history of heart attack, and metabolic equivalents were significantly correlated with apathy (P < 0.05). Partial correlations adjusting for these factors revealed significant correlations between behavioral apathy and a measure of executive function and the other apathy subscale with a measure of attention. Conclusion. Findings revealed that apathy was not prevalent in this sample though associated with medical variables. Apathy was largely unrelated to cognitive function. This pattern may be a result of the mild levels of cardiovascular disease and cognitive dysfunction in the current sample. Future studies in samples with severe cardiovascular disease or neuropsychological impairment may provide insight into these associations.
背景。精神疾病共病在心血管疾病患者中很常见，文献表明这一人群可能存在冷漠风险。本研究调查了心血管疾病患者中冷漠的患病率及其与认知功能各方面的关系。方法。来自门诊心脏病诊所的123名参与者完成了一套简短的神经心理测试、心脏压力测试以及人口统计学信息、病史和抑郁症状自评量表。参与者还完成了冷漠评估量表以量化冷漠程度。结果。这些受试者报告的冷漠和抑郁程度有限。抑郁症状增加、心脏病发作史和代谢当量与冷漠显著相关（P<0.05）。对这些因素进行校正后的偏相关分析显示，行为冷漠与执行功能测量指标之间存在显著相关性，另一个冷漠子量表与注意力测量指标之间存在显著相关性。结论。研究结果表明，尽管冷漠与医学变量相关，但在本样本中并不普遍。冷漠在很大程度上与认知功能无关。这种模式可能是由于当前样本中心血管疾病和认知功能障碍程度较轻所致。未来对患有严重心血管疾病或神经心理损伤的样本进行的研究可能会深入了解这些关联。
