药物对木炭和阴离子结合树脂的吸附作用。

Drug adsorption to charcoals and anionic binding resins.

al-Shareef A H, Buss D C, Routledge P A

Department of Pharmacology and Therapeutics, University of Wales College of Medicine, Llandough Hospital, Penarth, S. Glamorgan, UK.

Hum Exp Toxicol. 1990 Mar;9(2):95-7. doi: 10.1177/096032719000900206.

Abstract

The in-vitro binding of four drugs with differing physiochemical properties to two commercial charcoal preparations and two anionic binding resins was studied at 37 degrees C and pH 7.4. 2. The two charcoal preparations (Carbomix and Medicoal) behaved similarly and adsorbed metoclopramide and antipyrine to a greater degree than warfarin or paracetamol. 3. Cholestyramine had a significantly greater maximum adsorption capacity (K2) for warfarin and significantly lower adsorption capacity for paracetamol and metoclopramide than did the charcoals. 4. Colestipol behaved similarly but also bound metoclopramide to a significantly greater extent than did either cholestyramine or charcoal and antipyrine to a significantly lesser extent than did Carbomix. 5. There appeared to be no consistent relationship between the maximum adsorption capacity of the adsorbents for the drugs tested and the physicochemical properties of those drugs (e.g. basic or acidic structure, pKa or molecular weight).

摘要

在37摄氏度和pH值7.4的条件下，研究了四种具有不同理化性质的药物与两种市售活性炭制剂和两种阴离子结合树脂的体外结合情况。2. 两种活性炭制剂（Carbomix和Medicoal）表现相似，对甲氧氯普胺和安替比林的吸附程度高于华法林或对乙酰氨基酚。3. 消胆胺对华法林的最大吸附容量（K2）显著高于活性炭，而对对乙酰氨基酚和甲氧氯普胺的吸附容量则显著低于活性炭。4. 考来替泊表现相似，但对甲氧氯普胺地结合程度也显著高于消胆胺或活性炭，对安替比林的结合程度则显著低于Carbomix。5. 所测试药物的吸附剂最大吸附容量与这些药物的理化性质（例如碱性或酸性结构、pKa或分子量）之间似乎没有一致的关系。