Gottschall S, Falkenhagen D, Schmitt E, Courtney J M, Klinkmann H
Biomed Biochim Acta. 1984;43(2):245-8.
An investigation has been made of the drug removal properties and blood compatibility of activated charcoal and resin haemoadsorbents . The adsorbents were Norit RBX1 peat-based extruded charcoal, spherical charcoal as used in the Sorin Biomedica Detoxyl 2 column and 2 cross-linked polystyrene-based macroreticular resins. Drug removal properties were assessed in terms of in vitro adsorption efficiency of each adsorbent for 11 different drugs. The blood compatibility of the charcoals and macroreticular resins was evaluated in an in vitro haemoperfusion circuit by measuring the changes in platelet and leucocyte levels in human blood caused by contact with the adsorbent. The results of the investigation indicate advantages in using spherical charcoal haemoadsorbents .
对活性炭和树脂血液吸附剂的药物清除特性及血液相容性进行了研究。吸附剂包括诺芮特RBX1泥炭基挤压炭、索林生物医学公司Detoxyl 2柱中使用的球形炭以及两种交联聚苯乙烯基大孔树脂。根据每种吸附剂对11种不同药物的体外吸附效率评估药物清除特性。通过测量人体血液与吸附剂接触引起的血小板和白细胞水平变化，在体外血液灌流回路中评估炭和大孔树脂的血液相容性。研究结果表明使用球形炭血液吸附剂具有优势。
