他汀类药物的抗动脉粥样硬化机制。

Anti-atherosclerotic mechanisms of statin therapy.

机构信息

Institut für Kardiovaskuläre Physiologie, Goethe-Universität, Frankfurt, Germany.

出版信息

Curr Opin Pharmacol. 2013 Apr;13(2):260-4. doi: 10.1016/j.coph.2013.01.004. Epub 2013 Feb 9.

DOI:10.1016/j.coph.2013.01.004

Abstract

HMG-CoA-Reductase inhibitors, also known as statins, are currently the most powerful cholesterol-lowering drugs available on the market. Clinical trials and experimental evidence suggest that statins have anti-atherosclerotic effects. These are in part consequence of lipid lowering but also result from pleiotropic actions of the drugs. In this article, the anti-atherosclerotic actions of statins will be reviewed.

摘要

羟甲基戊二酰辅酶 A 还原酶抑制剂，也称为他汀类药物，是目前市场上最有效的降胆固醇药物。临床试验和实验证据表明，他汀类药物具有抗动脉粥样硬化作用。这些作用部分是由于降低血脂，但也是药物的多效性作用的结果。本文将综述他汀类药物的抗动脉粥样硬化作用。