Kim Sung-Wan, Kang Hee-Ju, Jhon Min, Kim Ju-Wan, Lee Ju-Yeon, Walker Adam J, Agustini Bruno, Kim Jae-Min, Berk Michael
Department of Psychiatry, Chonnam National University Medical School, Gwangju, South Korea.
IMPACT Strategic Research Centre, School of Medicine, Deakin University, Geelong, VIC, Australia.
Front Psychiatry. 2019 Mar 5;10:103. doi: 10.3389/fpsyt.2019.00103. eCollection 2019.
Statins, which are widely used to treat hypercholesterolemia, have anti-inflammatory and anti-oxidant effects. These are thought to be responsible for the potential effects of statins on various psychiatric disorders. In this study, we comprehensively review the literature to investigate the effects of statins on various psychiatric disorders including depression, schizophrenia, and dementia. In addition, we review adverse effects and drug interactions of statins to give clinically useful information guiding statin use in the psychiatric field. Statins seem useful in reducing depression, particularly in patients with physical disorders such as cardiovascular disease. In patients with schizophrenia, negative symptoms may be reduced by adjuvant statin therapy. Studies on cohorts at risk for dementia have generally shown protective effects of statins, while those on treatment for dementia show inconsistent results. In conclusion, statins used in combination with conventional psychotropic medications may be effective for various psychiatric disorders including depression, schizophrenia, and dementia. Further study is required to determine optimal doses and duration of statin use for the treatment of psychiatric disorders.
他汀类药物被广泛用于治疗高胆固醇血症，具有抗炎和抗氧化作用。这些作用被认为是他汀类药物对各种精神障碍产生潜在影响的原因。在本研究中，我们全面回顾文献，以调查他汀类药物对包括抑郁症、精神分裂症和痴呆症在内的各种精神障碍的影响。此外，我们还回顾了他汀类药物的不良反应和药物相互作用，以提供临床上有用的信息，指导他汀类药物在精神科领域的使用。他汀类药物似乎有助于减轻抑郁，尤其是在患有心血管疾病等躯体疾病的患者中。在精神分裂症患者中，辅助使用他汀类药物治疗可能会减轻阴性症状。对有患痴呆症风险的队列研究通常显示他汀类药物具有保护作用，而对痴呆症治疗的研究结果则不一致。总之，他汀类药物与传统精神药物联合使用可能对包括抑郁症、精神分裂症和痴呆症在内的各种精神障碍有效。需要进一步研究以确定治疗精神障碍时他汀类药物的最佳剂量和使用时长。
