School of Life Science, Shanxi University, Taiyuan 030006, Shanxi Province, China.
Micron. 2013 Apr;47:24-32. doi: 10.1016/j.micron.2013.01.002. Epub 2013 Jan 28.
Cadmium (Cd) is one of the most common pollutants in the environment and induces a range of tissue changes or damages and organ dysfunction. To explore the morphological changes in the hepatopancreas, freshwater crabs Sinopotamon henanense were exposed to water-borne Cd for 72h. Histologically, cellular swelling and apoptosis were observed, and to a lesser degree, necrosis. Ultrastructurally, there were changes in the nucleus and mitochondria with swelling, membrane disruption, cristae shorten or disappearance and mitochondria rupture. Numerous autolysomes occurred and may contribute to the damages to the crab treated with high Cd concentrations. The cell coat and P/Ca granules were gradually reduced when the Cd concentration increased. The RER displayed twisting, expansion with ribososomes detachment and crack in crabs treated with high Cd concentration. Saccules, vacuoles and vesicles of the Golgi complex may disaggregate expressly in the highest Cd group. Microvilli were not the first affected target. Thus, different organelles and cellular structures of freshwater crab were damaged at different stages of the Cd-induced injury. Apoptosis was the notable cell damage induced by Cd and presumed to be ascribed to various organelle injuries. Mitochondria are probably the primary and the critical target of Cd intoxication.
镉 (Cd) 是环境中最常见的污染物之一，可诱导一系列组织变化或损伤和器官功能障碍。为了研究肝胰腺的形态变化，将河南华溪蟹暴露于水基 Cd 中 72h。组织学观察到细胞肿胀和细胞凋亡，程度较轻的为细胞坏死。超微结构观察到细胞核和线粒体肿胀，膜破裂，嵴缩短或消失，线粒体破裂。大量自噬体的出现可能导致高 Cd 浓度处理的蟹受损。随着 Cd 浓度的增加，细胞外套和 P/Ca 颗粒逐渐减少。内质网在高 Cd 浓度处理的蟹中显示扭曲、扩张，核糖体脱离和出现裂痕。高尔基体的囊泡、空泡和小泡在最高 Cd 组中明显分离。微绒毛不是首先受到影响的靶标。因此，不同细胞器和细胞结构在 Cd 诱导损伤的不同阶段受到损伤。凋亡是 Cd 诱导的显著细胞损伤，推测归因于各种细胞器损伤。线粒体可能是 Cd 中毒的主要和关键靶标。
