Department of Pharmaceutical Sciences, Faculty of Chemistry, Universidad de la República, Uruguay.
Eur J Pharm Sci. 2013 Mar 12;48(4-5):825-9. doi: 10.1016/j.ejps.2013.01.016. Epub 2013 Feb 9.
Venous plasma drug concentrations are routinely monitored in order to determine pharmacokinetic parameters or to establish relationships with drug pharmacodynamic and clinical effects. Arterial drug concentration is higher than the respective venous concentration during the period where drug input of the substance predominates, whereas venous drug concentration is higher during the long period where drug elimination becomes the main process. This arterial-venous difference responds to current bioavailability and clearance of the drug-individual systems. Following the vein/artery plasma drug concentration ratio at a non-eliminating organ it is possible to monitor both parameters time by time. This way of following up the pharmacokinetic systems allows us to detect any changes in drug absorption or disposition more efficiently, without the need of a long period of time and regardless the duration of such system modification.
为了确定药代动力学参数或建立药物药效动力学和临床效果的关系，通常会监测静脉血浆药物浓度。在药物输入物质占主导地位的时期，动脉药物浓度高于相应的静脉浓度，而在药物消除成为主要过程的长时间内，静脉药物浓度较高。这种动静脉差异反映了当前药物个体系统的生物利用度和清除率。在非消除器官中，静脉/动脉血浆药物浓度比值可以随时监测两个参数。这种监测药代动力学系统的方法可以更有效地检测药物吸收或处置的任何变化，而无需长时间，也不受系统改变持续时间的影响。
