Chiou W L, Lam G
Int J Clin Pharmacol Ther Toxicol. 1982 May;20(5):197-203.
Arterial-venous blood or plasma concentration differences and their implications for renal clearance studies are reviewed. In common practice peripheral venous blood or plasma is used for absolute clearance studies employing timed-interval methods following single dosing. However, this is theoretically inappropriate or incorrect because of the systemic arterial-venous blood or plasma concentration difference. Many examples showing arterial-venous differences, together with brief theoretical discussions of factors affecting the differences, are presented. The implications in clearance studies of other organs such as lungs, liver, and the gastrointestinal tract are also discussed.
本文综述了动静脉血或血浆浓度差异及其对肾脏清除率研究的影响。在常规实践中，外周静脉血或血浆用于单次给药后采用定时间隔法的绝对清除率研究。然而，由于体循环动静脉血或血浆浓度差异，这在理论上是不合适或不正确的。文中给出了许多显示动静脉差异的例子，并对影响这些差异的因素进行了简要的理论讨论。还讨论了肺、肝和胃肠道等其他器官在清除率研究中的意义。
