超重会增加城市哮喘儿童对室内污染物的敏感性。
Being overweight increases susceptibility to indoor pollutants among urban children with asthma.
机构信息
Division of Pediatric Respiratory Sciences, Department of Pediatrics, Johns Hopkins School of Medicine, Johns Hopkins Hospital, Baltimore, MD 21287, USA.
出版信息
J Allergy Clin Immunol. 2013 Apr;131(4):1017-23, 1023.e1-3. doi: 10.1016/j.jaci.2012.12.1570. Epub 2013 Feb 10.
BACKGROUND
Both being overweight and exposure to indoor pollutants, which have been associated with worse health of asthmatic patients, are common in urban minority populations. Whether being overweight is a risk factor for the effects of indoor pollutant exposure on asthma health is unknown.
OBJECTIVES
We sought to examine the effect of weight on the relationship between indoor pollutant exposure and asthma health in urban minority children.
METHODS
One hundred forty-eight children (age, 5-17 years) with persistent asthma were followed for 1 year. Asthma symptoms, health care use, lung function, pulmonary inflammation, and indoor pollutants were assessed every 3 months. Weight category was based on body mass index percentile.
RESULTS
Participants were predominantly African American (91%) and had public health insurance (85%). Four percent were underweight, 52% were normal weight, 16% were overweight, and 28% were obese. Overweight or obese participants had more symptoms associated with exposure to fine particulate matter measuring less than 2.5 μm in diameter (PM2.5) than normal-weight participants across a range of asthma symptoms. Overweight or obese participants also had more asthma symptoms associated with nitrogen dioxide (NO2) exposure than normal-weight participants, although this was not observed across all types of asthma symptoms. Weight did not affect the relationship between exposure to coarse particulate matter measuring between 2.5 and 10 μm in diameter and asthma symptoms. Relationships between indoor pollutant exposure and health care use, lung function, or pulmonary inflammation did not differ by weight.
CONCLUSION
Being overweight or obese can increase susceptibility to indoor PM2.5 and NO2 in urban children with asthma. Interventions aimed at weight loss might reduce asthma symptom responses to PM2.5 and NO2, and interventions aimed at reducing indoor pollutant levels might be particularly beneficial in overweight children.
背景
超重和接触室内污染物与哮喘患者健康状况恶化有关，这在城市少数民族人群中很常见。目前尚不清楚超重是否是室内污染物暴露对哮喘健康影响的一个风险因素。
目的
我们旨在研究体重对城市少数民族儿童中室内污染物暴露与哮喘健康之间关系的影响。
方法
148 例（年龄 5-17 岁）持续性哮喘患儿随访 1 年。每 3 个月评估哮喘症状、医疗保健使用情况、肺功能、肺部炎症和室内污染物。体重类别基于体重指数百分位。
结果
参与者主要为非裔美国人（91%），并享有公共健康保险（85%）。4%的参与者体重不足，52%的参与者体重正常，16%的参与者超重，28%的参与者肥胖。超重或肥胖参与者比体重正常参与者在一系列哮喘症状中与细颗粒物（PM2.5）暴露相关的症状更多。超重或肥胖参与者也与二氧化氮（NO2）暴露相关的哮喘症状比体重正常参与者更多，尽管并非所有类型的哮喘症状均如此。体重并未影响到粗颗粒物（直径 2.5-10μm）暴露与哮喘症状之间的关系。室内污染物暴露与医疗保健使用、肺功能或肺部炎症之间的关系不因体重而异。
结论
超重或肥胖可能会增加城市哮喘儿童对室内 PM2.5 和 NO2 的易感性。旨在减肥的干预措施可能会减轻 PM2.5 和 NO2 暴露对哮喘症状的反应，而旨在降低室内污染物水平的干预措施可能对超重儿童特别有益。
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