Grammer Leslie C, Weiss Kevin B, Pedicano Jennifer B, Kimmel Linda G, Curtis Laura S, Catrambone Catherine D, Lyttle Christopher S, Sharp Lisa K, Sadowski Laura S
Division of Allergy-Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
J Asthma. 2010 Jun;47(5):491-5. doi: 10.3109/02770901003801980.
Urban minority populations experience increased rates of obesity and increased asthma prevalence and severity. Objective. The authors sought to determine whether obesity, as measured by body mass index (BMI), was associated with asthma quality of life or asthma-related emergency department (ED)/urgent care utilization in an urban, community-based sample of adults.
This is a cross-sectional analysis of 352 adult subjects (age 30.9 +/- 6.1, 77.8% females, forced expiratory volume in one second (FEV(1))% predicted = 87.0% +/- 18.5%) with physician-diagnosed asthma from a community-based Chicago cohort. Outcome variables included the Juniper Asthma Quality of Life Questionnaire (AQLQ) scores and health care utilization in the previous 12 months. Bivariate tests were used as appropriate to assess the relationship between BMI or obesity status and asthma outcome variables. Multivariate regression analyses were performed to predict asthma outcomes, controlling for demographics, income, depression score, and beta-agonist use.
One hundred ninety-one (54.3%) adults were obese (BMI > 30 kg/m(2)). Participants with a higher BMI were older (p = .008), African American (p < .001), female (p = .002), or from lower income households (p = .002). BMI was inversely related to overall AQLQ scores (r = -.174, p = .001) as well as to individual domains. In multivariate models, BMI remained an independent predictor of AQLQ. Obese participants were more likely to have received ED/urgent care for asthma than nonobese subjects (odds ratio [OR] = 1.8, p = .036).
In a community-based sample of urban asthmatic adults, obesity was related to worse asthma-specific quality of life and increased ED/urgent care utilization. However, compared to other variables measured such as depression, the contribution of obesity to lower AQLQ scores was relatively modest.
城市少数族裔人群肥胖率上升，哮喘患病率及严重程度也有所增加。目的：作者试图确定在一个以社区为基础的城市成年样本中，以体重指数（BMI）衡量的肥胖是否与哮喘生活质量或与哮喘相关的急诊科（ED）/紧急护理利用情况有关。
这是一项对来自芝加哥一个社区队列的352名成年受试者（年龄30.9±6.1岁，77.8%为女性，一秒用力呼气量（FEV₁）预计值 = 87.0%±18.5%）进行的横断面分析，这些受试者均有医生诊断的哮喘。结局变量包括杜松哮喘生活质量问卷（AQLQ）得分以及过去12个月的医疗保健利用情况。采用适当的双变量检验来评估BMI或肥胖状态与哮喘结局变量之间的关系。进行多变量回归分析以预测哮喘结局，并对人口统计学、收入、抑郁评分和β受体激动剂使用情况进行控制。
191名（54.3%）成年人肥胖（BMI>30 kg/m²）。BMI较高的参与者年龄较大（p = 0.008）、非裔美国人（p < 0.001）、女性（p = 0.002）或来自低收入家庭（p = 0.002）。BMI与总体AQLQ得分（r = -0.174，p = 0.001）以及各个领域均呈负相关。在多变量模型中，BMI仍然是AQLQ的独立预测因素。肥胖参与者因哮喘接受ED/紧急护理的可能性高于非肥胖受试者（优势比[OR] = 1.8，p = 0.036）。
在一个以社区为基础的城市哮喘成年样本中，肥胖与较差的哮喘特异性生活质量以及增加的ED/紧急护理利用情况有关。然而，与所测量的其他变量如抑郁相比，肥胖对较低AQLQ得分的影响相对较小。
