Department of Gastroenterology and Hepatology, Academic Medical Centre, Amsterdam, The Netherlands.
Cancer Epidemiol. 2013 Jun;37(3):330-5. doi: 10.1016/j.canep.2013.01.007. Epub 2013 Feb 9.
The effectiveness of colorectal cancer (CRC) screening programs depends on repeated participation. Little is known on later rounds in programs that use the fecal immunochemical test (FIT), in particular whether previous participants are likely to participate again, and if non-participants persist in declining. We compared overall participation in a second round to that in a first round, and evaluated differences in participation rates based on previous response.
Asymptomatic persons aged 50-74 years were invited to a second round of a FIT-based CRC screening pilot. We assessed the participation rate overall and within second round subgroups of previous participants, previous non-participants, and first time invitees. We also assessed whether participation rates were similar for males and females and for age groups.
In the first screening round, 2871 of 5309 invitees returned the FIT (participation rate of 57%). This was higher than in the second in which 3187 of 5925 participated (54%; p = 0.0008). Second round participation rate was 85% (2034/2385) among previous participants, 18% (325/1826) among previous non-participants and 48% (828/1714) among first time invitees (p < .0001). Overall, males and persons aged under 55 were less likely to participate.
Participation in a second round of FIT-screening was significantly lower than in the first round, largely due to a drop in participation in first round participants, and a relatively low response among first time invitees. This loss of uptake was partially compensated by a willingness to be screened in previous non-participants.
结直肠癌（CRC）筛查计划的有效性取决于重复参与。在使用粪便免疫化学试验（FIT）的计划的后续轮次中，人们对其了解甚少，特别是之前的参与者是否有可能再次参与，以及未参与者是否继续拒绝。我们比较了第二轮的总体参与率与第一轮的参与率，并根据之前的反应评估了参与率的差异。
邀请 50-74 岁的无症状者参加基于 FIT 的 CRC 筛查试验的第二轮。我们评估了第二轮的总体参与率，以及第一轮的既往参与者、既往未参与者和首次受邀者的第二轮亚组的参与率。我们还评估了男性和女性以及不同年龄组的参与率是否相似。
在第一轮筛查中，5309 名受邀者中有 2871 人返回了 FIT（参与率为 57%）。这高于第二轮的 5925 名受邀者中有 3187 人参与（参与率为 54%；p = 0.0008）。第二轮的既往参与者参与率为 85%（2034/2385），既往未参与者为 18%（325/1826），首次受邀者为 48%（828/1714）（p <.0001）。总体而言，男性和 55 岁以下的人不太可能参与。
FIT 筛查第二轮的参与率明显低于第一轮，主要是由于第一轮参与者的参与率下降，以及首次受邀者的相对低响应率。这种参与率的下降部分被以前未参与者愿意接受筛查所补偿。
