白消安、氟达拉滨和阿仑单抗预处理及无关脐血移植治疗镰状细胞病患儿 - Suppr

Busulfan, fludarabine, and alemtuzumab conditioning and unrelated cord blood transplantation in children with sickle cell disease.

作者信息

Radhakrishnan Kavita, Bhatia Monica, Geyer Mark B, Del Toro Gustavo, Jin Zhezhen, Baker Courtney, Harrison Lauren, Morris Erin, Baxter-Lowe Lee Ann, Cairo Mitchell S

出版信息

Biol Blood Marrow Transplant. 2013 Apr;19(4):676-7. doi: 10.1016/j.bbmt.2013.02.002. Epub 2013 Feb 9.

DOI:10.1016/j.bbmt.2013.02.002

PMID:23403308

Abstract

摘要

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Busulfan, fludarabine, and alemtuzumab conditioning and unrelated cord blood transplantation in children with sickle cell disease.白消安、氟达拉滨和阿仑单抗预处理及无关脐血移植治疗镰状细胞病患儿

Biol Blood Marrow Transplant. 2013 Apr;19(4):676-7. doi: 10.1016/j.bbmt.2013.02.002. Epub 2013 Feb 9.

Busulfan, fludarabine, and alemtuzumab as a reduced toxicity regimen for children with malignant and nonmalignant diseases improves engraftment and graft-versus-host disease without delaying immune reconstitution.马利兰、氟达拉滨和阿仑单抗作为降低毒性方案用于治疗儿童恶性和非恶性疾病可改善植入和移植物抗宿主病，而不延迟免疫重建。

Biol Blood Marrow Transplant. 2012 Nov;18(11):1656-63. doi: 10.1016/j.bbmt.2012.05.006. Epub 2012 May 15.

Am J Hematol. 2015 Nov;90(11):1021-6. doi: 10.1002/ajh.24141. Epub 2015 Oct 12.

Biol Blood Marrow Transplant. 2014 Apr;20(4):581-6. doi: 10.1016/j.bbmt.2013.12.564. Epub 2013 Dec 24.

Fludarabine-based reduced intensity conditioning for stem cell transplantation of Fanconi anemia patients from fully matched related and unrelated donors.基于氟达拉滨的减低强度预处理方案用于范可尼贫血患者接受来自全相合亲属及非亲属供者的干细胞移植。

Biol Blood Marrow Transplant. 2006 Jul;12(7):712-8. doi: 10.1016/j.bbmt.2006.03.002.

Reduced intensity conditioning using intravenous busulfan, fludarabine and rabbit ATG for children with nonmalignant disorders and CML.采用静脉注射白消安、氟达拉滨和兔抗胸腺细胞球蛋白对患有非恶性疾病和慢性粒细胞白血病的儿童进行减低强度预处理。

Bone Marrow Transplant. 2006 Feb;37(3):263-9. doi: 10.1038/sj.bmt.1705240.

Biol Blood Marrow Transplant. 2017 Sep;23(9):1587-1592. doi: 10.1016/j.bbmt.2017.05.027. Epub 2017 May 31.

Single-unit umbilical cord blood transplantation from unrelated donors in patients with hematological malignancy using busulfan, thiotepa, fludarabine and ATG as myeloablative conditioning regimen.采用白消安、噻替哌、氟达拉滨和 ATG 作为清髓性预处理方案，对血液系统恶性肿瘤患者进行非血缘单份脐带血移植。

Bone Marrow Transplant. 2012 Oct;47(10):1287-93. doi: 10.1038/bmt.2012.13. Epub 2012 Feb 13.

Fludarabine and busulfan as a myeloablative conditioning regimen for allogeneic stem cell transplantation in high- and standard-risk leukemic patients.氟达拉滨和白消安作为高风险和标准风险白血病患者异基因干细胞移植的清髓性预处理方案。

Bone Marrow Transplant. 2007 Jul;40(2):105-10. doi: 10.1038/sj.bmt.1705685. Epub 2007 Apr 30.

Conditioning with purine analogs leads to good engraftment rates of immunodepleted grafts for aplastic anemia.嘌呤类似物预处理可提高免疫抑制后骨髓移植治疗再生障碍性贫血的植入率。

Biol Blood Marrow Transplant. 2013 Apr;19(4):584-8. doi: 10.1016/j.bbmt.2012.12.017. Epub 2012 Dec 25.

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Selecting patients with sickle cell disease for gene addition or gene editing-based therapeutic approaches: Report on behalf of a joint EHA Specialized Working Group and EBMT Hemoglobinopathies Working Party consensus conference.为基于基因添加或基因编辑的治疗方法选择镰状细胞病患者：代表欧洲血液学协会（EHA）专门工作组和欧洲血液与骨髓移植协会（EBMT）血红蛋白病工作组联合共识会议撰写的报告

Hemasphere. 2025 Mar 13;9(3):e70089. doi: 10.1002/hem3.70089. eCollection 2025 Mar.

Donor chimerism and immune reconstitution following haploidentical transplantation in sickle cell disease.同种异体移植治疗镰状细胞病中的供者嵌合体和免疫重建。

Front Immunol. 2022 Dec 9;13:1055497. doi: 10.3389/fimmu.2022.1055497. eCollection 2022.

Choice of Donor Source and Conditioning Regimen for Hematopoietic Stem Cell Transplantation in Sickle Cell Disease.镰状细胞病造血干细胞移植的供体来源选择和预处理方案

J Clin Med. 2019 Nov 15;8(11):1997. doi: 10.3390/jcm8111997.

The Safe Recipient of SSC Transplantation Prepared by Heat Shock With Busulfan Treatment in Mice.热休克预处理联合白消安处理供体小鼠以制备安全的心脏移植供体

Cell Transplant. 2018 Oct;27(10):1451-1458. doi: 10.1177/0963689718794126. Epub 2018 Sep 6.

Stem cell transplantation in sickle cell disease: therapeutic potential and challenges faced.镰状细胞病中的干细胞移植：治疗潜力与面临的挑战

Expert Rev Hematol. 2018 Jul;11(7):547-565. doi: 10.1080/17474086.2018.1486703. Epub 2018 Jun 20.

Alternative donor hematopoietic stem cell transplantation for sickle cell disease.镰状细胞病的替代供体造血干细胞移植

Blood Adv. 2017 Jun 28;1(16):1215-1223. doi: 10.1182/bloodadvances.2017005462. eCollection 2017 Jul 11.

Alternative Donor/Unrelated Donor Transplants for the β-Thalassemia and Sickle Cell Disease.β地中海贫血和镰状细胞病的替代供体/非亲属供体移植

Adv Exp Med Biol. 2017;1013:123-153. doi: 10.1007/978-1-4939-7299-9_5.

Pharmacokinetics, Pharmacodynamics, and Pharmacogenomics of Immunosuppressants in Allogeneic Hematopoietic Cell Transplantation: Part II.异基因造血细胞移植中免疫抑制剂的药代动力学、药效学和药物基因组学：第二部分。

Clin Pharmacokinet. 2016 May;55(5):551-93. doi: 10.1007/s40262-015-0340-9.

Hematopoietic stem cell transplantation in sickle cell disease: patient selection and special considerations.镰状细胞病中的造血干细胞移植：患者选择及特殊考量

J Blood Med. 2015 Jul 10;6:229-38. doi: 10.2147/JBM.S60515. eCollection 2015.

Alternative donor transplant of benign primary hematologic disorders.良性原发性血液系统疾病的替代供体移植

Bone Marrow Transplant. 2015 May;50(5):619-27. doi: 10.1038/bmt.2015.1. Epub 2015 Feb 9.

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Busulfan, fludarabine, and alemtuzumab conditioning and unrelated cord blood transplantation in children with sickle cell disease.

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