自发性高血压脑卒中大鼠模型（SHRSP）脑白质的 MRI 组织学研究。
An MRI-histological study of white matter in stroke-free SHRSP.
机构信息
Stroke and Dementia Research Centre, St Georges University of London, London, UK.
出版信息
J Cereb Blood Flow Metab. 2013 May;33(5):760-3. doi: 10.1038/jcbfm.2013.14. Epub 2013 Feb 13.
Abstract
Hypertension is associated with cerebral small vessel disease (SVD) and with diffuse white matter hyperintensities (WMH) on T2-weighted magnetic resonance imaging (MRI). We tested whether stroke-prone spontaneously hypertensive rats (SHRSP), a model of chronic hypertension, exhibit WMH. Male SHRSP (age 10 months) without stroke symptoms were compared with age-matched male WKY rats. Stroke-prone spontaneously hypertensive rats exhibited no WMH on MRI scans (T2, T2*, diffusion tensor imaging) and no neuropathological lesions. While leptomeningeal arteries exhibited fibrohyaline wall thickening, with decreased smooth muscle actin relative to WKY, deep penetrating arterioles within the caudate nuclei had no vasculopathy. We conclude that WMH are not an obligate feature of stroke-free SHRSP aged up to 10 months.
摘要
高血压与脑小血管疾病（SVD）和 T2 加权磁共振成像（MRI）上的弥漫性脑白质高信号（WMH）有关。我们测试了易发生中风的自发性高血压大鼠（SHRSP），一种慢性高血压模型，是否存在 WMH。无中风症状的雄性 SHRSP（10 月龄）与年龄匹配的雄性 WKY 大鼠进行比较。MRI 扫描（T2、T2*、弥散张量成像）显示易发生中风的自发性高血压大鼠无 WMH，也无神经病理学损伤。虽然软脑膜动脉有纤维玻璃样壁增厚，平滑肌肌动蛋白相对 WKY 减少，但尾状核内的深穿支小动脉没有血管病变。我们的结论是，10 月龄以下无中风的 SHRSP 不一定有 WMH。
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