Karck J, von Spiessen L, Rohn K, Meyer-Lindenberg A
Klinik für Kleintiere, Tierärztliche Hochschule Hannover, Bünteweg 9, 30559 Hannover.
Tierarztl Prax Ausg K Kleintiere Heimtiere. 2013;41(1):37-45.
The aim of this study was to evaluate whether the degree of renal insufficiency and/or high blood pressure in cats with chronic renal insufficiency (CRI) is related to the degree of change in the fundus and whether there are differences in blood pressure between the different accompanying diseases.
In cats with CRI and/or hypertensive retinopathy and healthy cats, the following examinations were carried out: physical examination, ophthalmic examination, measurement of the blood pressure using Doppler ultrasonography, complete blood count, serum biochemical analyses, including serum thyroxine (T4) concentration, urinalysis and ultrasonography of the heart and abdomen.
A total of 69 diseased and 24 healthy cats were examined. 53/69 cats displayed changes of the fundus, 17/69 cats had uveitis and 4/69 had hyphaema. Cats of the control group had no ocular changes and a mean systolic blood pressure of 13 ± 6.7 mmHg, which was not related to age. The degree of the CRI was negligibly negatively correlated with the degree of fundic changes and blood pressure. The blood pressure was significantly positively correlated with the degree of fundus changes and age. Cats with systemic hypertension, which only suffered from CRI, had a significantly lower blood pressure than cats with an additional left ventricular hypertrophy or only a left ventricular hypertrophy, hyperthyroidism or primary hypertension.
According to the results of the present study, the degree of the CRI is not a reliable prognostic factor for the development and the degree of fundic change. The blood pressure in hypertensive cats with CRI without additional diseases is lower compared to hypertensive cats with CRI and left ventricular hypertrophy, left ventricular hypertrophy alone, hyperthyroidism or primary hypertension.
本研究旨在评估慢性肾功能不全（CRI）猫的肾功能不全程度和/或高血压与眼底变化程度是否相关，以及不同伴随疾病之间的血压是否存在差异。
对患有CRI和/或高血压性视网膜病变的猫以及健康猫进行了以下检查：体格检查、眼科检查、使用多普勒超声测量血压、全血细胞计数、血清生化分析（包括血清甲状腺素（T4）浓度）、尿液分析以及心脏和腹部超声检查。
共检查了69只患病猫和24只健康猫。69只猫中有53只出现眼底变化，17只患有葡萄膜炎，4只患有前房积血。对照组的猫没有眼部变化，平均收缩压为13±6.7 mmHg，与年龄无关。CRI的程度与眼底变化程度和血压呈可忽略不计的负相关。血压与眼底变化程度和年龄呈显著正相关。仅患有CRI的全身性高血压猫的血压明显低于伴有左心室肥厚或仅左心室肥厚、甲状腺功能亢进或原发性高血压的猫。
根据本研究结果，CRI的程度不是眼底变化发展和程度的可靠预后因素。与患有CRI并伴有左心室肥厚、单纯左心室肥厚、甲状腺功能亢进或原发性高血压的高血压猫相比，不伴有其他疾病的CRI高血压猫的血压较低。
