Baral Aradhita, Kumar Pankaj, Pathak Rajiv, Chowdhury Shantanu
Proteomics and Structural Biology Unit, Institute of Genomics and Integrative Biology, CSIR, Mall Road, Delhi 110 007, India.
Mol Biosyst. 2013 Jul;9(7):1568-75. doi: 10.1039/c3mb25492e. Epub 2013 Feb 13.
G-quadruplex biology gained interest based on evidence supporting its widespread role as elements that can control or modulate gene regulation. This followed initial prediction based on computational analysis that found prevalence of quadruplex motifs in promoters of many bacterial and other organisms. In parallel, further evidence was found indicating the function of quadruplex motifs in replication, recombination and also DNA repair. In this review, we summarize recent findings that provide a new perspective by introducing quadruplex motifs in roles that support involvement during epigenetic events, in determining evolutionary selection and as possible determinants of quantitative expression traits (eQTL) across populations.
基于支持其作为可控制或调节基因调控元件的广泛作用的证据，G-四链体生物学引起了人们的关注。这是基于计算分析的初步预测，该分析发现许多细菌和其他生物体的启动子中存在四链体基序。与此同时，还发现了进一步的证据，表明四链体基序在复制、重组以及DNA修复中的功能。在本综述中，我们总结了最近的发现，这些发现通过引入四链体基序在支持表观遗传事件参与、确定进化选择以及作为跨群体定量表达性状（eQTL）的可能决定因素方面的作用，提供了一个新的视角。
