Scaria Vinod, Hariharan Manoj, Arora Amit, Maiti Souvik
GN Ramachandran Knowledge Center for Genome Informatics, Institute of Genomics and Integrative Biology CSIR, Mall Road, Delhi 110 007, India.
Nucleic Acids Res. 2006 Jul 1;34(Web Server issue):W683-5. doi: 10.1093/nar/gkl299.
G-quadruplex secondary structures, which play a structural role in repetitive DNA such as telomeres, may also play a functional role at other genomic locations as targetable regulatory elements which control gene expression. The recent interest in application of quadruplexes in biological systems prompted us to develop a tool for the identification and analysis of quadruplex-forming nucleotide sequences especially in the RNA. Here we present Quadfinder, an online server for prediction and bioinformatics of uni-molecular quadruplex-forming nucleotide sequences. The server is designed to be user-friendly and needs minimal intervention by the user, while providing flexibility of defining the variants of the motif. The server is freely available at URL http://miracle.igib.res.in/quadfinder/.
G-四链体二级结构在诸如端粒等重复DNA中发挥结构作用，在其他基因组位置作为控制基因表达的可靶向调控元件也可能发挥功能作用。最近对四链体在生物系统中应用的兴趣促使我们开发一种工具，用于识别和分析尤其是RNA中形成四链体的核苷酸序列。在此，我们展示了Quadfinder，一个用于单分子形成四链体核苷酸序列预测和生物信息学分析的在线服务器。该服务器设计得用户友好，用户只需最少干预，同时提供定义基序变体的灵活性。该服务器可通过网址http://miracle.igib.res.in/quadfinder/免费获取。
